- Syntheses of prodelphinidin B3 and C2, and their antitumor activities through cell cycle arrest and caspase-3 activation
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Total synthesis of prodelphinidin B3 and C2 have been accomplished. The key step is Lewis acid-mediated equimolar condensations between a catechin and/or gallocatechin nucleophile and a gallocatechin electrophile. The antitumor effects of synthetic prodel
- Fujii, Wataru,Toda, Kazuya,Kawaguchi, Koichiro,Kawahara, Sei-Ichi,Katoh, Miyuki,Hattori, Yasunao,Fujii, Hiroshi,Makabe, Hidefumi
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p. 3543 - 3550
(2013/05/21)
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- CHARACTERIZATION AND TRYPSIN INHIBITOR ACTIVITY OF PROANTHOCYANIDINS FROM VICIA FABA
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In a chemical investigation epicatechin, epigallocatechin, the procyanidins B-1, B-3 and B-4, and the prodelphinidins gallocatechin-(4α,8)-catechin, gallocatechin-(4α,8)-epicatechin and gallocatechin-(4α,8)-epigallocatechin have been isolated from the testa of faba beans and characterized by means of spectroscopic methods.Proanthocyanidin samples were compared for their trypsin inhibitory activity.The results suggest that the degree of polymerization, the number of phenolic hydroxyl groups and the 2,3-stereochemistry of the constituent units affect remarkably the strength of the inhibition.
- Helsper, Johannes P. F. G.,Kolodziej, Herbert,Hoogendijk, Johanna M.,Norel, Arend van
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p. 1255 - 1260
(2007/10/02)
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