- Continuous preparing method for amodiaquine hydrochloride
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The invention provides a continuous preparing method for amodiaquine hydrochloride. The method is a continuous three-step reaction preparing method and has the advantages that an intermediate product prepared in the reaction step is not separated, and amodiaquine hydrochloride is directly prepared. The method is simple in technology, less equipment is occupied, operation is simple, water serves as reaction solvent, pollution of a system is small, and the method is suitable for industrial production.
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Paragraph 0027
(2016/10/27)
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- Lewis acid-catalyzed generation of C-C and C-N bonds on π-deficient heterocyclic substrates
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Focused microwave irradiation of a series of halogenated nitrogen heterocycles and different kinds of nucleophiles in the presence of a catalytic amount of indium trichloride leads to the efficient and completely regioselective generation of aromatic C-C and C-N bonds. The method is simple, rapid, general and inexpensive, and can be performed without the use of dried solvents. Most of the synthetized compounds are new and in many cases the work-up required only filtration. Furthermore, this is the first example of the use of a Lewis acid as a catalyst for heteroarylation, vinylation and amination reactions on π-deficient heterocyclic substrates.
- Staderini, Matteo,Bolognesi, Maria Laura,Menndez, J. Carlos
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supporting information
p. 185 - 195
(2015/01/30)
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