- Benzotriazole-assisted thioacylation
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Benzotriazole reagents for thioacylation (RCSBt), thiocarbamoylation (RR'NCSBt), aryl/alkoxy-thioacylation (ROCSBt), and aryl/alkylthiothioacylation (RSCSBt) are synthesized, and their utility is assessed by syntheses of representative heteroaryl thioureas 3a-g, thioamides 15a-s, thionoesters 16a-h, thiocarbamates 17a-e, dithiocarbamates 18a-d, thiocarbonates 19a-c, and dithiocarbonates 20a-c.
- Katritzky, Alan R.,Witek, Rachel M.,Rodriguez-Garcia, Valerie,Mohapatra, Prabhu P.,Rogers, James W.,Cusido, Janet,Abdel-Fattah, Ashraf A. A.,Steel, Peter J.
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p. 7866 - 7881
(2007/10/03)
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- 1-(Alkyl/Arylthiocarbamoyl)benzotriazoles as Stable Isothiocyanate Equivalents: Synthesis of Di- and Trisubstituted Thioureas
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1-(Alkyl/arylthiocarbamoyl)benzotriazoles 4a-i were synthesized in yields of 91-99% from bis(benzotriazolyl)methanethione (3). Reagents 4a-g were then used as isothiocyanate equivalents for the efficient synthesis of 10 secondary and 14 tertiary thioureas
- Katritzky, Alan R.,Ledoux, Stephane,Witek, Rachel M.,Nair, Satheesh K.
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p. 2976 - 2982
(2007/10/03)
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