- Addition of benzyl ethers to alkynes: A metal-free synthesis of 1: H -isochromenes
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Bromotrimethylsilane (TMSBr)-promoted intramolecular cyclization of (o-arylethynyl)benzyl ethers to form 1H-isochromenes at room temperature is reported. Further studies indicated that vinyl carbocations are the reaction intermediates which are stabilized by the conjugated aryl groups. Thus, O-addition of benzyl ethers/tetrahydropyrans to alkynes was achieved under metal-free, acidic conditions. These reaction conditions were compatible with an alkynyl Prins reaction; therefore, 1H-isochromenes were produced directly from alkynyl benzaldehydes and alkynyl alcohols using a one-pot procedure. This journal is
- Chen, Cheng-Chun,Hou, Duen-Ren,Kotipalli, Trimurtulu,Kuan, Tzu-Hsuan
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p. 10390 - 10402
(2021/12/17)
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- Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines
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The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.
- Wang, Yiqiong,Huang, Fei,Zhang, Songlin
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p. 5178 - 5181
(2020/08/13)
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- Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds
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We report a new photocatalytic protocol for the redox-neutral isomerization of cyclic alcohols to linear ketones via C-C bond scission. Mechanistic studies demonstrate that key alkoxy radical intermediates in this reaction are generated via the direct homolytic activation of alcohol O-H bonds in an unusual intramolecular PCET process, wherein the electron travels to a proximal radical cation in concert with proton transfer to a weak Br?nsted base. Effective bond strength considerations are shown to accurately forecast the feasibility of alkoxy radical generation with a given oxidant/base pair.
- Yayla, Hatice G.,Wang, Huaiju,Tarantino, Kyle T.,Orbe, Hudson S.,Knowles, Robert R.
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p. 10794 - 10797
(2016/09/09)
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- Novel compound capable of activating Nrf2, and pharmaceutical compositions comprising the same
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The present invention provides a novel compound which can activate Nrf2 that is a transcription factor for expression of the quinone reductase gene. Therefore the compound is effective for inhibiting apoptosis and preventing and treating brain nerve disea
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Paragraph 0996-0999
(2016/10/08)
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- Anodic cyclization of dimethyl 2-(5-aryl-5-oxopentyl)malonates into the corresponding dimethyl 2-aroylcyclopentane-1,1-dicarboxylates
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A wide range of dimethyl 2-(5-aryl-5-oxopentyl)malonates was electrooxidized in methanol, in the presence of catalytic amount of potassium iodide, to give the corresponding dimethyl 2-aroylcyclopentane-1,1- dicarboxylates in high yields. The reactions were carried out under extremely mild reaction conditions, in which the optimal amount of electrolytic current ranged from 2.24 to 2.35 Fmol-1. The reaction presumably proceeded via a two-electron oxidation process, in which iodide ions played an important role as the electron carrier between the anode and the substrate.
- Okimoto, Mitsuhiro,Yamamori, Haruki,Hoshi, Masayuki,Yoshida, Takashi
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p. 1299 - 1302
(2014/03/21)
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- Synthesis and Nrf2 activating ability of thiourea and vinyl sulfoxide derivatives
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Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inf
- Shim, Young Sun,Hwang, Hyun Sook,Nam, Ghilsoo,Choi, Kyung Il
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p. 2317 - 2320
(2013/09/24)
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- Halogen-substituted triarylpyrazoles: potential estrogen receptor-alpha selective radiopharmaceuticals
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Halogen-substituted analogs of a pyrazole ligand for the estrogen receptor have been synthesized. These analogs retain much of the affinity preference of the parent ligand for the estrogen receptor alpha sybtype (ERα) vs beta subtype (ERβ).
- Vijaykumar, Dange,Katzenellenbogen, John A.
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p. S342 - S344
(2007/10/03)
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