- Substituted pyrimidine compound, pharmaceutical composition thereof and application of compound
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The invention relates to a substituted pyrimidine compound, a pharmaceutical composition thereof and application of the compound. The substituted pyrimidine compound has excellent inhibitory activityon mutant EGFR and mutant HER2, and has excellent pharma
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- Nitrogen-containing heterocyclic compound, pharmaceutical composition and application thereof
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The invention provides a nitrogen-containing heterocyclic compound shown as general formula (I) in the specification or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotope label or isomer thereof, and further provides a phar
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- HETEROARYL COMPOUNDS FOR KINASE INHIBITION
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Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.
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Paragraph 460
(2016/04/26)
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- CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS
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This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
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