69411-06-9

Basic information

• Product Name: 4-CHLORO-2,6-DIFLUOROANILINE
• Synonyms: 4-CHLORO-2,6-DIFLUOROANILINE;BenzenaMine,4-chloro-2,6-difluoro-;2,6-difluoro-4-chloro aniline
• CAS NO: 69411-06-9
• Molecular Formula: C₆H₄ClF₂N
• Molecular Weight: 163.55
• Product Categories: pharmacetical
• Mol File: 69411-06-9.mol

Chemical Properties

• Melting Point: 47-50℃
• Boiling Point: 180.9 °C at 760 mmHg
• Flash Point: 63.2 °C
• Appearance: /
• Density: C₆H₄ClF₂N
• Vapor Pressure: 0.874mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-CHLORO-2,6-DIFLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2,6-DIFLUOROANILINE(69411-06-9)
• EPA Substance Registry System: 4-CHLORO-2,6-DIFLUOROANILINE(69411-06-9)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: 6.1
• Hazardous Substances Data: 69411-06-9(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Chemicals Industry:
4-Chloro-2,6-difluoroaniline is used as an intermediate for the production of agricultural chemicals. Its unique chemical structure contributes to the development of effective and targeted agrochemicals, enhancing crop protection and yield.
Used in Dyes Industry:
In the dyes industry, 4-chloro-2,6-difluoroaniline serves as a key intermediate in the synthesis of various dyes. Its presence in the molecular structure of dyes imparts specific color characteristics and properties, making it valuable for a wide range of applications, including textiles, plastics, and printing inks.
Used in Pharmaceutical Industry:
4-Chloro-2,6-difluoroaniline is utilized as an intermediate in the production of pharmaceuticals. Its unique chemical properties allow for the development of new drugs with specific therapeutic effects, contributing to advancements in medicine and healthcare.
It is important to handle 4-chloro-2,6-difluoroaniline with care, as it can cause irritation to the skin, eyes, and respiratory system. As a hazardous substance, proper precautions must be taken during its handling, storage, and use to ensure safety and minimize environmental impact.

InChI:InChI=1/C6H4ClF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2

Upstream product

• 5509-65-9 2,6-difluoroaniline 

Downstream Products

• 338992-42-0 N-7-benzyloxy-(4-chloro-2,6-difluorophenyl)-6-methoxy-4-quinazilinylamine 
• 270076-30-7 4-Chloro-2,6-difluorophenyl Isocyanate 

Relevant articles and documents

[jihidorokinorinon[jihidorokinorinon] compound

5 - [To] {[ (4 - chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on production of the -8 - fluoro -2. [Solution] 5 - {[ (4 - chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on a crystal -8 - fluoro -2,(1) 5 - {[ (4 - Chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on an acceptable solvent -8 - fluoro -2 pharmaceutical manufacturing process flow, and (2) (1) cooling the resulting solution was stirred at the reflux process by providing a method comprising the steps of crystallization. [Drawing] no

METHODS FOR PRODUCING CONDENSED HETEROCYCLIC COMPOUND AND INTERMEDIATE OF THE SAME

PROBLEM TO BE SOLVED: To provide methods for producing 5-{[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl]methoxy}-8-fluoro-3,4-dihydroxyquinolin-2(1H)-one and an intermediate of the same, 1-(4-chloro-2,6-difluorophenyl)piperidin-4-one. SOLUTION: Provided are: a method for producing 1-(4-chloro-2,6-difluorophenyl)piperidin-4-one, comprising a step of reacting 4-chloro-2,6-difluoroaniline 4-methylbenzenesulfonate with 1-ethyl-1-(2-methylallyl)-4-oxopiperidin-1-ium iodide; and a method for producing 5-{[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxypiperidin-4-yl]methoxy}-8-fluoro-3,4-dihydroxyquinolin-2(1H)-one by using 1-(4-chloro-2,6-difluorophenyl)piperidin-4-one. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)

QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS

The invention relates to quinazoline derivatives of the formula I:- wherein: m is an integer from 1 to 3; R 1 represents halogeno or C 1-3 alkyl; X 1 represents -O-; R 2 is selected from one of the following three groups: 1) C 1-5 alkylR 3 (wherein R 3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 alkoxy; 2) C 2-5 alkenylR 3 (wherein R 3 is as defined hereinbefore); 3) C 2-5 alkynylR 3 (wherein R 3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

3-[Benz(ox/thi)azol-7-yl]-1h-pyrimidine-2,4-diones

The invention relates to herbicidally effective 3-{benz(ox/thi)azol-7-yl}-1H-pyrimidine-2,4-diones of formula (I) wherein X=oxygen or sulphur, Y=oxygen or sulphur; Z=chemical bond, C1-C4-alkylene, O, S, SO, SO2; R1/s