694471-97-1

Basic information

• Product Name: (4-(3-PYRIDYLOXY)PHENYL)SULFONYL CHLORIDE HYDROCHLORIDE
• Synonyms: 4-(PYRIDIN-3-YLOXY)BENZENESULFONYL CHLORIDE HYDROCHLORIDE;(4-(3-PYRIDYLOXY)PHENYL)SULFONYL CHLORIDE HYDROCHLORIDE;4-(3-PYRIDYLOXY)PHENYLSULPHONYL CHLORIDE HYDROCHLORIDE;4-(3-Pyridyloxy)Benzenesulfonyl Chloride Hydrochloride;4-(Pyridin-3-yloxy)benzene-1-sulfonylchloride hydrochloride;4-(Pyridin-3-yloxy)benzene-1-sulfonyl chloride
• CAS NO: 694471-97-1
• Molecular Formula: C₁₁H₈ClNO₃S
• Molecular Weight: 306.17
• Mol File: 694471-97-1.mol

Chemical Properties

• Boiling Point: 392.1 °C at 760 mmHg
• Flash Point: 191 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 2.03E-07mmHg at 25°C
• CAS DataBase Reference: (4-(3-PYRIDYLOXY)PHENYL)SULFONYL CHLORIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(3-PYRIDYLOXY)PHENYL)SULFONYL CHLORIDE HYDROCHLORIDE(694471-97-1)
• EPA Substance Registry System: (4-(3-PYRIDYLOXY)PHENYL)SULFONYL CHLORIDE HYDROCHLORIDE(694471-97-1)

Safety Data

• Hazard Codes: C
• RIDADR: UN1759
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 694471-97-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(4-(3-Pyridyloxy)phenyl)sulfonyl chloride hydrochloride is used as a reagent for the introduction of sulfonyl chloride groups into organic molecules, which is crucial for various chemical reactions and the formation of new compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (4-(3-Pyridyloxy)phenyl)sulfonyl chloride hydrochloride is used as a key intermediate in the synthesis of drugs, contributing to the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Synthesis:
Similarly, in agrochemicals, this compound is utilized for the synthesis of pesticides and other crop protection agents, enhancing agricultural productivity and crop protection.
Used as a Protecting Group in Organic Chemistry:
(4-(3-Pyridyloxy)phenyl)sulfonyl chloride hydrochloride serves as a protecting group in organic chemistry, which is essential for the selective reaction of certain functional groups while preventing others from reacting under certain conditions. This selective protection is vital for complex organic synthesis processes.

InChI:InChI=1/C11H8ClNO3S.ClH/c12-17(14,15)11-5-3-9(4-6-11)16-10-2-1-7-13-8-10;/h1-8H;1H

Upstream product

• 1000340-09-9 C₁₁H₉NO₄S 
• 2176-45-6 3-phenoxypyridine 

Relevant articles and documents

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Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

COMPOUNDS WITH PGD2 ANTAGONIST ACTIVITY

Compounds of general formula (I); wherein R1, R2, R3 and R4 are independently hydrogen, halo, -C1-C6 alkyl, -O(C1-C6 alkyl), -C1-C6 alkyl(C3-C7 cycloalkyl), -CON(R9)2, -SOR9, -S02R9, -S02N(R9)2, -N(R9)2, -NR9OR9, -C02R9, COR9, -SR9, -OH, -N02 or -CN; each R9 independently hydrogen or C1-C6 alkyl, R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl; R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or an aromatic moiety, any of which may optionally be substituted with one or more substituents selected from halo, -SOR13 -S02R13, -R14, -OR14, -CON(R14)2 -SOR14, -S02R14, -S02N(R14) -S02N(R14)2, -N(R 14)2, NR14COR14, -CO2R14, COR14, -SR14, -N02 or -CN; wherein R13 is a 5 to 7 membered heterocyclic ring, and each R14 is independently hydrogen, alkyl or aryl, the aryl being optionally substituted by -R9, -OR9, -CON(R9)2, -SOR9 -S02R9, -S02N(R9)2, -N(R9)2, NR9COR9, -C02R9, -COR9, -SR9, halo, -N02 or -CN, wherein R9 is as defined above; provided that when R1, R3 and R4 are hydrogen and R2 is hydrogen, halogen or -0(C1-C6)alkyl, R8 is not unsubstituted phenyl or phenyl substituted by halo, C1-C6 alkyl, -0(C1-C6)alkyl, -S(C1-C6)alkyl or -CO(C1-C6)alkyl, or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs therof are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis