- CATIONIC LIPID
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The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.
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Paragraph 0058; 0060
(2017/11/17)
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- Influence of positional isomers on the macroscale and nanoscale architectures of aggregates of racemic hydroxyoctadecanoic acids in their molecular gel, dispersion, and solid states
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Inter/intramolecular hydrogen bonding of a series of hydroxystearic acids (HSAs) are investigated. Self-assembly of molecular gels obtained from these fatty acids with isomeric hydroxyl groups is influenced by the position of the secondary hydroxyl group. 2-Hydroxystearic acid (2HSA) does not form a molecular dimer, as indicated by FT-IR, and growth along the secondary axis is inhibited because the secondary hydroxyl group is unable to form intermolecular H-bonds. As well, the XRD long spacing is shorter than the dimer length of hydroxystearic acid. 3-Hydroxystearic acid (3HSA) forms an acyclic dimer, and the hydroxyl groups are unable to hydrogen bond, preventing the crystal structure from growing along the secondary axis. Finally, isomers 6HSA, 8HSA, 10HSA, 12HSA, and 14HSA have similar XRD and FT-IR patterns, suggesting that these molecules all self-assemble in a similar fashion. The monomers form a carboxylic cyclic dimer, and the secondary hydroxyl group promotes growth along the secondary axis.
- Abraham, Shibu,Lan, Yaqi,Lam, Ricky S. H.,Grahame, Douglas A. S.,Kim, Jennifer Jae Hee,Weiss, Richard G.,Rogers, Michael A.
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experimental part
p. 4955 - 4964
(2012/07/13)
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- Synthesis and anti-cancer activity of C-ring-functionalized prodigiosin analogues
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Prodigiosin is the parent member of the 4-methoxypyrrolyldipyrromethene family of natural products and is known for its anti-cancer activity. A new series of analogues was synthesized, incorporating pendent functional esters and β-carbonyl substituents on the C-ring. The β-carbonyl group allowed for the facile isolation of the prodigiosenes, and the pendent esters allow for further derivatization. The novel prodigiosenes generally retain the anti-cancer activity of prodigiosin in 60 human cell lines derived from nine cancer cell types, with neither the conjugated /3-carbonyl group, as either ketone or ester, nor the pendent ester significantly reducing the anti-cancer activity of the core skeleton.
- Regourd, Jasmine,Ali, Adeeb Al-Sheikh,Thompson, Alison
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p. 1528 - 1536
(2008/02/02)
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- Process for producing ferrocenoyl derivatives
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Disclosed is a process for producing a ferrocenoyl derivative comprising the reaction of ferrocene derivative with monocarboxylic acid or dicarboxylic acid in the presence of a catalyst. The ferrocenoyl derivative obtained by said process is very useful as the intermediate product for various functional materials, among all, for the micelle forming agents (surfactants) in so-called Micellar Disruption Method or the intermediate product of it.
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- SYNTHESE BIOLOGISCH AKTIVER UNGESAETTIGTER AMIDE
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The synthesis of seven naturally occurring unsaturated amides is described.
- Bohlmann, Ferdinand,Ganzer, Michael,Krueger, Martin,Nordhoff, Erhard
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p. 123 - 128
(2007/10/02)
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- Liposomal Membranes. 2. Synthesis of a Novel Pyrene-Labeled Lecithin and Structural Studies on Liposomal Bilayers
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A novel pyrene-labeled phosphatidylcholine, 1,2-bis-sn-glycero-3-phosphorylcholine (DPDL), was synthesized for use in structural studies on the liposomal bilayers.From the fluorescence measurements on DPDL incorporated into the phospholipid bilayers as well as in organic solvents and aqueous buffered solutions, the following interesting information was obtained. (1) The probe DPDL is intercalated in a well-ordered fashion in the very hydrophobic domain of egg and dipalmitoylphosphatidylcholine bilayers. (2) Without cholesterol and /or below the phase-transition temperature, DPDL is arranged with the lipid-separated conformation in the shrunk liposomal bilayers (Figure 9d). (3) Increasing the mobility of lipid molecules by the addition of cholesterol and/or by elevating temperatures causes a conformational change of DPDL in the bilayers from the lipid-separated conformation to the intimate one (Figure 9c).
- Sunamoto, Junzo,Kondo, Hiroki,Nomura, Tadashi,Okamoto, Hiroshi
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p. 1146 - 1152
(2007/10/02)
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