- Studies in synthesis and tautomerism of new warfarin derivatives
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Substituted 4-hydroxy-7-methoxy-benzopyran-2-(/-V)-one on Michael condensation with different a,p-unsaturated ketones gave various warfarin derivatives. 1H NMR studies of these compounds in deuteriochloroform showed three interconverting tautomeric structures, two of which are cyclic diastereomeric hemiketals, while the third one is the open chain intermediate form; whereas the 1H NMR in deuteriodimethylsulfoxide shows existence of only two diastereomeric hemiketal forms.
- Soman, Shubhangi S.,Patel,Jethawa, Komal B.,Baloni, Radhika
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p. 233 - 236
(2013/09/24)
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- THERAPEUTIC AGENT
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A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.
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Page/Page column 58
(2010/11/08)
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- Synthesis of a Diels-Alder precursor for the Elisabethin A skeleton
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A synthesis of a precursor 2 for the Elisabethin A skeleton is reported. Containing a masked quinone and a (E,Z)-diene sub-unit, it has the required elements for the envisaged intramolecular Diels-Alder reaction to form the tricyclic system of Elisabethin A. Starting from methylresorcinol, the sequence involves the preparation of an arylacetic acid, which was α-alkylated by a chiral building block. Subsequent HWE reaction and cis-selective Wittig olefination furnished the diene with the desired geometry.
- Heckrodt, Thilo J.,Mulzer, Johann
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p. 1857 - 1866
(2007/10/03)
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