- Heterocyclic compounds as inhibitors of factor VIIa
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The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
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Page/Page column 82; 83
(2008/06/13)
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- Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions
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A high yielding one-pot procedure for the generation of 2-substituted benzimidazoles directly from 2-nitroanilines by in situ reduction and cyclization using a microwave procedure is described.
- VanVliet, David S.,Gillespie, Paul,Scicinski, Jan J.
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p. 6741 - 6743
(2007/10/03)
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- ONE ATOM LYNCH PIN TRANSFORMATIONS OF GOLD'S REAGENT
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A series of o-phenylenediamines and o-aminophenols have been reacted with Gold's reagent to yield benzimidazoles and benzoxazoles, respectively.Additionally, o-hydroxyacetophenone and anthranilamide, when reacted with Gold's reagent, were found to produce chromone and 3H-quinazoline-4-one, respectively.These transformations represent the use of Gold's reagent as a one atom lynch pin.
- Gupton, John T.,Correia, Keith F.,Foster, Bruce S.
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p. 365 - 376
(2007/10/02)
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