Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy
Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic.
Frackowiak, Anna,Skibiński, Przemys?aw,Gawe?, Wies?aw,Zaczyńska, Ewa,Czarny, Anna,Gancarz, Roman
experimental part
p. 1001 - 1007
(2010/04/26)
Chemical synthesis and in vitro antitumor activity of quinizarin glycoside analogs
A series of new glycoside derivatives of quinizarin were synthesized and characterized by NMR and IR spectrometry, and in vitro antitumor activity of some of these derivatives was evaluated against the mouse leukaemia P388 and the human leukaemia HL-60 cell lines by the standard MTT assay. They were proven to possess moderate antitumor activity. Copyright Taylor & Francis Group, LLC.
Sun, Xiaofei,Ji, Li,Ren, Sumei,Wan, Shengbiao,Jiang, Tao
experimental part
p. 4116 - 4124
(2009/04/11)
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