- Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer
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Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolec
- Huang, Hanmin,Yu, Min,Zhang, Tianze
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p. 10501 - 10505
(2021/08/20)
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- Indole-3-acetic acids and hetero analogues by one pot synthesis including Heck cyclisation
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Bz-substituted indole-3-acetic acid ethyl esters (14e-g) and heteroanalogues, i.e. thienopyrroles (14a,c) and selenolopyrrole (14d), were prepared starting from N-BOC protected o-iodo aryl amines. Allylation with ethyl 4-bromocrotonate, followed by palladium-catalysed ring closure in a one pot reaction, yielded N-BOC protected indoles (13e-g), thienopyrroles (13a-c), and selenolopyrrole (13d). The BOC group was readily removed thermally after adsorption on silica. Oxothienopyrroles (11a-c) were similarly prepared.
- Wensbo, David,Annby, Ulf,Gronowitz, Salo
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p. 10323 - 10342
(2007/10/02)
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