- egypt for pulls Wei intermediate and its preparation method and application
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The invention discloses an elvitegravir intermediate and a preparation method and application thereof. The elvitegravir intermediate has a chemical structure shown as FORMULA II, in which X is Cl, Br or I, and a chemical structure shown as FORMULA III. Application of the elvitegravir intermediate to synthesis of elvitegravir has the advantages as follows: simple preparation process, mild reaction conditions, cheap and easily-available raw materials, high total molar yield, simple posttreatment, high product purity and the like, is very suitable for large-scale production and has a great significance and a practical value for low-cost and large-scale preparation of high-purity elvitegravir.
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- COMBINATIONS COMPRISING A 4-ISOQUINOLONE DERIVATIVE AND ANTI-HIV AGENTS
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The present invention relates to a combination therapy for treating an HIV infection or inhibiting integrase comprising (S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ("Compound A"
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