- Method for synthesizing ethyl cucurbituride lactone spice
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Compared with the existing similar products, the method comprises the following steps: preparing 2 -oxobutyric acid ethyl ester by Grignard reaction under the condition of absolute ethyl acetate as a starting raw material and carrying out Grignard reaction on potassium carbonate. After the needed carbon skeleton is cyclized under the action of acetaldehyde, ethylcucurbituric acid lactone is obtained, and the technological process is reduced. The reaction solvent and the extractant are recycled, so that the cost is reduced, the purity of the product is 98.36% through gas chromatography, and higher reaction yield is ensured.
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Paragraph 0046-0061
(2021/11/14)
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- Synthesis of 2-Hydroxy-3-methyl-2-hexen-4-olid
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The title compound 13a, a substance used in food-flavoring, was synthesized in 89percent overall yield, starting from methyl 2-hydroxy-3-butenoate (3a).The key step in this transformation is the isomerization of the C=C bond in 3a which yielded methyl 2-oxobutanoate as an intermediate.The latter underwent a self-condensation yielding 2-hydroxy-4-(methoxycarbonyl)-3-methyl-2-hexen-4-olid (11a), which, after hyrolysis and decarboxylation, gave 13a.In addition the syntheses of five other compounds related to 13a are reported.
- Stach, Hans,Huggenberg, Walter,Hesse, Manfred
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p. 369 - 374
(2007/10/02)
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