Phosphine catalyzed addition of long-chain dialkyl phosphites to electron-deficient alkenes
Conjugate addition of the long chain dialkyl phosphites to electron-deficient alkenes under PBu3 catalysis afforded the corresponding phosphonates in good yields in a short reaction time. Long chain alkyl groups in the phosphites were well tolerated in this transformation. The products of this reaction are of particular interest as components of lubrication oil composition.
Il’in, Anton,Gubaev, Arthur,Antonova, Anna,Khannanov, Arthur,Galkin, Vladimir
Convenient preparation of long-chain dialkyl phosphates: Synthesis of dialkyl phosphates
Reaction of phosphorus oxychloride with a primary alcohol (1.8 equiv) and triethylamine (1.8 equiv) in toluene, followed by filtration and treatment with steam, gives dialkyl phosphates in good yield and essentially free from trialkyl phosphate contamination. Georg Thieme Verlag Stuttgart · New York.
Aitken, R. Alan,Collett, Chris J.,Mesher, Shaun T. E.
scheme or table
p. 2515 - 2518
(2012/09/05)
Synthesis of AZT 5′-O-hydrogen phospholipids and their derivatives
A series of AZT 5′-O-hydrogen phospholipids 5a-e were synthesized by a tandem transesterification of diphenyl phosphite (DPP) with AZT and a long-chain alcohol. This method has the merits of easy operation and high yields. The corresponding phosphonates, phosphorothionates and phosphoroselenoates of 5d and 5e and the phosphoramidates conjugated with L-amino acid methyl ester 9a and 9b were also synthesized.
Novel approach to the synthesis of AZT 5′-O-hydrogen phospholipids
A series of AZT 5′-O-hydrogen phospholipids were synthesized by a tandem transesterification of diphenyl phosphite with AZT and a long-chain alcohol. The method possesses the merits of ease of operation and high yields. It can also be extended to synthesize other biological phospholipids.