700348-67-0Relevant articles and documents
Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
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Page/Page column 23, (2008/06/13)
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
Synthesis of enantiopure angularly condensed [2.2]paracyclophanes containing five-membered rings
Minuti, Lucio,Taticchi, Aldo,Marrocchi, Assunta,Lanari, Daniela,Broggi, Alessandra,Gacs-Baitz, Eszter
, p. 481 - 487 (2007/10/03)
Optically active angularly condensed [2.2]paracyclophanes containing five-membered rings have been synthesized by a two-step approach based on the Diels-Alder cycloaddition of (S)-(+)-4-vinyl[2.2]paracyclophane. Structural analysis by NMR spectroscopy is presented. These helicenophanes containing a cyclopentane ring show extraordinarily high specific rotations. This phenomenon has been discussed in terms of structural modifications caused by the replacement of the benzene unit with a cyclopentane ring.