- Practical approaches to the matrix metalloproteinase inhibitor Trocade (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315
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Stereoselective methods were found to efficiently prepare 2- and 3-substituted succinates with anti configuration. In the synthesis of Trocade 1, the hydantoinmethyl residue was introduced by alkylation of the non-chelated potassium enolate 19 with the br
- Hilpert, Hans
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p. 7675 - 7683
(2007/10/03)
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- Hypoglycaemically active 2-alkyl- or -alkenyl-hydrazono propionic acid derivatives
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A 2-hydrazonopropionic acid derivative of the formula STR1 wherein R is an aliphatic hydrocarbon radical, and X is a valency bond or a divalent aliphatic hydrocarbon radical containing up to 4 carbon atoms, with the proviso that when X is a valency bond, R cannot be saturated cycloalkyl, or a physiologically compatible salt, lower alkyl ester or amide thereof, which exhibit hypoglycaemic activity.
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