- Mild, General, and Regioselective Synthesis of 2-Aminopyridines from Pyridine N -Oxides via N -(2-Pyridyl)pyridinium Salts
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A synthesis of 2-aminopyridines from pyridine N-oxides via their corresponding N-(2-pyridyl)pyridinium salts has been demonstrated and investigated. The reaction sequence features a highly regioselective conversion of the N-oxide into its pyridinium salt
- Xiong, Hui,Hoye, Adam T.
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supporting information
p. 371 - 375
(2022/01/27)
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- Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant
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A series of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) at the 2-position were synthesized and evaluated for treatment of Alzheimer's disease. In vitro assays demonstrated that most of the target compounds exhibit significant inhibition of Cu(II)-induced Aβ1–42aggregation, rapid H2O2scavenging and glutathione peroxidise (GPx)-like catalytic activity. Among these molecules, compound 9a is the most potent peroxide scavenger that possesses the ability to scavenge most H2O2within 200–220 min and possesses GPx-like activity (v0= 106.0 μM·min?1), enabling modulation of metal-induced Aβ aggregation.
- Wang, Bo,Wang, Zhiren,Chen, Hong,Lu, Chuan-Jun,Li, Xingshu
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p. 4741 - 4749
(2016/09/09)
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- Blue and white light electroluminescence in a multilayer OLED using a new aluminium complex
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Synthesis, structure, optical absorption, emission and electroluminescence properties of a new blue emitting Al complex, namely, bis-(2-amino-8- hydroxyquinolinato), acetylacetonato Al(III) are reported. Multilayer OLED using the Al complex showed blue emission at 465 nm, maximum brightness of ～ 425 cd/m2 and maximum current efficiency of 0.16 cd/A. Another multilayer OLED using the Al complex doped with phosphorescent Ir complex showed 'white' light emission, CIE coordinate (0.41, 0.35), maximum brightness of ～ 970 cd/m2 and maximum current efficiency of 0.53 cd/A. Indian Academy of Sciences.
- Nayak, Pabitra K.,Agarwal, Neeraj,Ali, Farman,Patankar, Meghan P.,Narasimhan,Periasamy
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scheme or table
p. 847 - 855
(2011/10/04)
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- First safe and practical synthesis of 2-amino-8-hydroxyquinoline
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The first safe and efficient synthesis of the important building block 2-amino-8-hydroxyquinoline (1) is described. Starting from the readily available N-oxide 3 of the cheap bulk chemical 8-hydroxyquinoline (2), the target compound is obtained in a two-step one pot procedure in good overall yield (53-66%) and purity (>98%) on a kilogram scale without chromatography.
- Storz, Thomas,Marti, Roger,Meier, Roland,Nury, Patrice,Roeder, Michael,Zhang, Kesheng
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p. 663 - 665
(2013/09/02)
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