An expedient synthesis of (±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide via a 3-bromoisoxazole intermediate
The excitatory, amino acid ± 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid hydrobromide was prepared in gram quantities in a 3.3% overall yield from methylbut 2-ynoate. The key step was the facile preparation of methyl 3-bromo-5-methylisoxazole-4-carboxylate.
Hanson, Robert N.,Mohamed, Fand A.
p. 345 - 348
(2007/10/03)
A Novel Synthesis of 3-Bromo-1,2,4-oxadiazoles
A novel synthesis of 3-bromo-1,2,4-oxadiazoles by 1,3-dipolar cycloaddition between bromocyanogen oxide and alkyl and aryl nitriles is described.
Humphrey, Guy R.,Wright, Stanley H.B.
p. 23 - 24
(2007/10/02)
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