- Beta-carbolines useful for treating inflammatory disease
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This invention provides beta-carboline compounds of formula III-A-aa: wherein Q, G, R1, R2, R3, and R6b are as described in the specification. The compounds are useful for treating diseases such as inflammatory diseases and cancer.
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Page/Page column 109-110
(2010/02/14)
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- Chelating diamide based rate enhancement of intramolecular alkene hydroaminations catalyzed by a neutral Sc(III) complex
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(Chemical Equation Presented) Neutral scandium amido complexes are viable catalysts for intramolecular alkene hydroamination. Catalytic activity is strongly coupled to the electronic character of the Sc(III) ligand environment with chelating diamide coord
- Joon, Young Kim,Livinghouse, Tom
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p. 4391 - 4393
(2007/10/03)
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- An evaluation of some hindered diamines as chiral modifiers of metal-promoted reactions
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Diamino analogues of the C2-symmetric chiral diphosphine ligands DuPHOS and BPE have been prepared and evaluated as chiral modifiers of the osmium tetraoxide dihydroxylation of stilbene. NMR experiments showed that these ligands were too bulky to coordinate to osmium. Less hindered analogues of these ligands were prepared and some were shown to act as ligands in dihydroxylation reactions but with poor enantioselectivity (e.e. 10%). The diamines have also been briefly evaluated as ligands in rhodium-catalyzed hydroformylation and copper-catalyzed phenolic coupling reactions. Once again, only low enantioselectivity was obtained.
- Illesinghe, Jayamini,Ebeling, Richard,Ferguson, Brett,Patel, Jim,Campi, Eva M.,Jackson, W. Roy,Robinson, Andrea J.
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p. 167 - 176
(2007/10/03)
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- Asymmetric syntheses of 2-substituted and 2,5-disubstituted pyrrolidines from (3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl[2,1-b]oxazolopyrrolidine
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Benzotriazole, 2,5-dimethoxytetrahydrofuran, and (S)-phenylglycinol in one step gave 80% of (3S, 5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl-[2,1- b]oxazolopyrrolidine (6), whose crystal structure was confirmed by X-ray crystallography. Novel chiral pyrrolidine synthon 6 reacts with organosilicon (allyltrimethylsilanes and vinyloxytrimethylsilanes), organophosphorus, organozinc, and Grignard reagents to afford chiral 2-substituted and 2,5- disubstituted pyrrolidines.
- Katritzky, Alan R.,Cui, Xi-Lin,Yang, Baozhen,Steel, Peter J.
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p. 1979 - 1985
(2007/10/03)
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- Diastereoselective synthesis of 2,5-dimethylpyrrolidines and 2,6- dimethylpiperidines by reductive amination of 2,5-hexanedione and 2,6- heptanedione with hydride reagents
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The reductive amination of 2,5-hexanedione and 2,6-heptanedione with ammonia and primary amines in the presence of hydride reagents afforded 2,5- dimethylpyrrolidines and 2,6-dimethylpiperidines with variable diastereoselectivity, as the cis/trans ratio was affected by the size of the ring formed and the steric and electronic properties of the nitrogen substituent. Increasing the bulkiness of the nitrogen substituent, the cis pyrrolidines and the trans-piperidines were obtained with enhanced selectivity.
- Boga,Manescalchi,Savoia
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p. 4709 - 4722
(2007/10/02)
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- THE SYNTHESIS OF EITHER (+) OR (-) TRANS-2,5-DIMETHYLPYRROLIDINE
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Trans-2,5-dimethylpyrrolidine, in either optical series, is prepared starting from D or L-alanine in an efficient and reasonably brief reaction sequence.
- Schlessinger, Richard H.,Iwanowicz, Edwin J.
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p. 2083 - 2086
(2007/10/02)
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