- Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives
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Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.
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Paragraph 0181; 0182; 0183
(2013/06/05)
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- 2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms
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Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright
- Frei, Reto,Breitbach, Anthony S.,Blackwell, Helen E.
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supporting information; experimental part
p. 5226 - 5229
(2012/07/03)
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- An iterative approach toward the synthesis of discrete oligomeric p-phenylene vinylene organic dyes employing aqueous Wittig chemistry
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Photovoltaic research has become increasingly prominent as the search for alternatives to fossil fuels are actively sought. A novel process for the iterative synthesis of discrete donor/acceptor-flanked oligostilbenes, key constituents in dye-sensitized solar cells, is described. The aqueous Wittig process is high yielding, proceeds with high (E)-stereoselectivity and allows facile product purification.
- McNulty, James,McLeod, David
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supporting information; experimental part
p. 5467 - 5470
(2011/11/01)
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- Highly Stereoselective and General Synthesis of (E)-Stilbenes and Alkenes by Means of an Aqueous Wittig Reaction
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The chemoselective formation of trialkyl(benzylidene) ylides in water and their Wittig reaction with aromatic and. aliphatic aldehydes provides a practical, stereoselective and environmentally benign route to valuable (E)-stilbenes and alkenes. The synthesis of the phytoalexin resveratrol is described, J.n addition, the method allows for a gram-scale synthesis of the anticancer agent DMU-212 utilizing no organic solvent at any stage. Wiley-VCH Verlag GmbH & Co. KGaA.
- McNulty, James,Das, Priyabrata
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supporting information; experimental part
p. 4031 - 4035
(2009/12/09)
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