Simple and efficient one step synthesis of functionalized flavanones and chalcones
A facile and highly efficient microwave-assisted synthesis of functionalized chalcones and flavanones based on the Claisen-Schmidt condensation reaction is reported. The method describes the synthesis of flavanones in single step with excellent yield and it was revealed that position and number of substituents on acetophenones and aromatic aldehydes played a very crucial and key role in the construction of flavanone derivatives. Among the thirty two synthesized compounds, five chalcones and one flavanone were novel compounds.
Albogami, Abdullah Saad,Karama, Usama,Mousa, Ahmed Amine,Khan,Al-Mazroa, Sara Abdullah,Alkhathlan, Hamad Z.
p. 619 - 626
(2012/10/30)
Synthesis of pyrazolines, isoxazoles and cyanopyridines as potential antimicrobial agents
3,5-Dichloro-2-hydroxyacetophenone 1 on treatment with aromatic aldehydes yields 3,5-dichloro-2-hydroxy-ω-arylidine acetophenones 2a-j which on cyclisation with hydrazine hydrate, hydroxylamine hydrochloride and malononitrile furnishes the corresponding 3
Shah, Manish,Patel, Pankaj,Korgaokar, Sushil,Parekh, Hansa
p. 1282 - 1286
(2007/10/03)
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