B(OMe)3 as a nonacidic iminium ion generator in Mannich- and Ugi-type reactions
Mannich-type reactions of aldehydes with secondary amines and a ketene silyl acetal were promoted by trimethoxyborane in DMSO to afford the corresponding β-amino esters in good yields. B(OMe)3 also promoted Ugi-type reactions of aldehydes with
Diarylborinic acid derivatives as a catalytic iminium ion generator in the mannich-type reaction using secondary amines, aldehydes, and ketene silyl acetals
Reactions of secondary amines, aldehydes, and ketene silyl acetals were efficiently promoted by catalytic amounts of diarylborinic acid esters, Ar 2B(OR), affording β-amino esters selectively with no formation of the corresponding β-hydroxy esters. Georg Thieme Verlag Stuttgart.
Tanaka, Yusuke,Hasui, Tomoaki,Suginome, Michinori
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p. 1239 - 1242
(2009/04/05)
Cu(acac)2 immobilized in ionic liquids: A recoverable and reusable catalytic system for aza-Michael reactions
Copper(II) acetylacetonate immobilized in ionic liquids efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds to produce the corresponding β-amino carbonyl compounds with great alacrity in excellent yields. The reactions are far more facile than those reported earlier. The recovered ionic liquid phase containing the copper catalyst can be reused for several cycles with consistent activity.
Kantam, M. Lakshmi,Neeraja,Kavita,Neelima,Chaudhuri, Mihir K.,Hussain, Sahid
p. 763 - 766
(2007/10/03)
LiClO4 accelerated Michael addition of amines to α,β-unsaturated olefins under solvent-free conditions
Several primary and secondary amines were added to α,β- unsaturated esters, nitriles, amides, and ketones to give the corresponding saturated amines mediated by solid lithium perchlorate under solvent-free and environmentally friendly conditions at room temperature.
Azizi, Najmedin,Saidi, Mohammad R.
p. 383 - 387
(2007/10/03)
Air- and moisture-stable cationic (diphosphine)palladium(II) complexes as hydroamination catalysts X-ray crystal structures of two complexes
A series of cationic (diphosphine)palladium(II) complexes have been prepared and fully characterized, including two crystal structures. These complexes were evaluated as catalysts for the hydroamination of acyclic alkenes. The reactivity of the catalysts is dependent on the nature of the diphosphine ligand and the substituents on the amine and alkene substrates.
Li, Kelin,Horton, Peter N.,Hursthouse, Michael B.,Hii, King Kuok Mimi
p. 250 - 257
(2007/10/03)
Synthesis and CNS activity of new 3-amino-3-arylpropionic acid derivatives
The synthesis of new analogues of methylphenidate and modafinil, derived from 3-amino-3-arylpropionic acids, is described. Central pharmacological properties were studied in mice.