704878-53-5

Basic information

• Product Name: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2H-TETRAZOLE-2-ACETIC ACID
• Synonyms: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2H-TETRAZOLE-2-ACETIC ACID;BUTTPARK 3\01-52;2-{5-[4-(trifluoromethyl)phenyl]-2H-1,2,3,4-tetrazol-2-yl}acetic acid
• CAS NO: 704878-53-5
• Molecular Formula: C₁₀H₇F₃N₄O₂
• Molecular Weight: 272.18
• Mol File: 704878-53-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2H-TETRAZOLE-2-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2H-TETRAZOLE-2-ACETIC ACID(704878-53-5)
• EPA Substance Registry System: 5-[4-(TRIFLUOROMETHYL)PHENYL]-2H-TETRAZOLE-2-ACETIC ACID(704878-53-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 704878-53-5(Hazardous Substances Data)

Upstream product

• 2251-79-8 5-(4’-trifluoromethylphenyl)-1H-tetrazole 
• 50907-43-2 [5-(4-trifluoromethyl-phenyl)-tetrazol-2-yl]-acetic acid ethyl ester 
• 455-18-5 4-CF₃C₆H₄CN 

Downstream Products

• 1010421-15-4 C₃₃H₃₄F₃N₇O₄S 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.