704885-44-9 Usage
Uses
Used in Pharmaceutical Industry:
4-ForMyl-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester is used as a key intermediate in the synthesis of epothilone-saccharide conjugates for the treatment of proliferative diseases. These conjugates are designed to improve the therapeutic efficacy and selectivity of epothilones by enhancing their solubility, stability, and targeted delivery to cancer cells.
In the development of novel anticancer agents, 4-ForMyl-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester plays a crucial role in the formation of epothilone-saccharide conjugates. These conjugates leverage the microtubule-stabilizing properties of epothilones to inhibit cell division and proliferation, particularly in cancer cells. The saccharide component of the conjugate can be further modified to enhance the selectivity and targeting of the compound to specific cancer cells, thereby reducing side effects and improving the overall therapeutic outcome.
Furthermore, the use of 4-ForMyl-2-Methoxyphenyl β-D-Glucopyranosiduronic Acid Triacetate Methyl Ester in the preparation of epothilone-saccharide conjugates allows for the exploration of new drug delivery systems and formulations. This can lead to the development of more effective and safer cancer treatments, as well as the potential for combination therapies with other anticancer agents.
Check Digit Verification of cas no
The CAS Registry Mumber 704885-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,4,8,8 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 704885-44:
(8*7)+(7*0)+(6*4)+(5*8)+(4*8)+(3*5)+(2*4)+(1*4)=179
179 % 10 = 9
So 704885-44-9 is a valid CAS Registry Number.
704885-44-9Relevant articles and documents
DRUG COMPOSITION FOR PARENTERAL ADMINISTRATION
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Paragraph 0031; 0032, (2019/05/16)
Provided is a curcumin pharmaceutical preparation that is highly water soluble, can maintain the concentration of free curcumin in the blood sufficiently high by being administered parenterally, can effectively obtain a pharmacological action of curcumin,
Curcumin glucuronides: Assessing the proliferative activity against human cell lines
Pal, Ashutosh,Sung, Bokyung,Bhanu Prasad, Basvoju A.,Schuber Jr., Paul T.,Prasad, Sahdeo,Aggarwal, Bharat B.,Bornmann, William G.
, p. 435 - 439 (2014/01/17)
A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat cell, U266, and A549 cell lines were reported. Biological data revealed that as much as 1 μM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 μM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.
