Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins
Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1μmol/cm2) provoked 50% oedema reduction, similarly to 0.25μmol/cm2 of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.
Curini, Massimo,Epifano, Francesco,Maltese, Federica,Marcotullio, Maria C.,Tubaro, Aurelia,Altinier, Gianmario,Gonzales, Sylvia Prieto,Rodriguez, Juan C.
p. 2241 - 2243
(2007/10/03)
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