Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent Gram-positive antibacterial activity
Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.
Jarvest, Richard L.,Berge, John M.,Brown, Murray J.,Brown, Pamela,Elder, John S.,Forrest, Andrew K.,Houge-Frydrych,O'Hanlon, Peter J.,McNair, David J.,Rittenhouse, Stephen,Sheppard, Robert J.
p. 665 - 668
(2007/10/03)
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