- Cross-linked heparin coatings and methods
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A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an adsorbable biomolecule such as a heparin activity biomolecule with at least one prosthetic hydrophobic unit, and a multifunctional crosslinking agent, such as a bis-variant of polyethylene glycol, polyethylene oxide, or polyethylene glycol, wherein the crosslinking is by means of covalent complexation through at least two functional groups of the multifunctional crosslinking agent.
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- Process for the preparation of lactic acid silyl esters
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Novel lactic acid silyl esters of the formula STR1 in which R represents alkyl or aryl, are obtained by a new process which comprises reacting a lactic acid of the formula STR2 with a chloromethylsilane of the formula STR3 in which R has the meaning indicated above, in the presence of a tertiary amine and, if appropriate, in the presence of an additional diluent, at temperatures between 50° and 120° C.
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