70862-22-5

Basic information

• Product Name: N(1)-acetylnorspermidine
• Synonyms: N(1)-acetylnorspermidine
• CAS NO: 70862-22-5
• Molecular Formula: C8H19N3O
• Molecular Weight: 173.25596
• Mol File: 70862-22-5.mol

Chemical Properties

• Boiling Point: 372.6°C at 760 mmHg
• Flash Point: 179.2°C
• Appearance: /
• Density: 0.967g/cm³
• Vapor Pressure: 9.48E-06mmHg at 25°C
• Refractive Index: 1.469
• CAS DataBase Reference: N(1)-acetylnorspermidine(CAS DataBase Reference)
• NIST Chemistry Reference: N(1)-acetylnorspermidine(70862-22-5)
• EPA Substance Registry System: N(1)-acetylnorspermidine(70862-22-5)

Safety Data

• Hazardous Substances Data: 70862-22-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H19N3O/c1-8(12)11-7-3-6-10-5-2-4-9/h10H,2-7,9H2,1H3,(H,11,12)

Upstream product

• 118508-79-5 N¹-acetyl-N³-(3-azidopropyl)-1,3-diaminopropane 
• 92954-42-2 N-acetyl-1-azido-3-aminopropane 
• 118508-76-2 N¹-acetyl-N³-(3-bromopropyl)-1,3-diaminopropane dihydrochloride 
• 56-18-8 bis(3-aminopropyl)amine 
• 604-68-2 α-D-glucopyranose peracetylate 

Relevant articles and documents

The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase

We have synthesized eight polyamine perylene diimides to conjugate the efficiency of perylene derivatives in stabilizing G-quadruplex structures and the polyamines' biological activity, due to specific interactions with different DNA domains. Our study was carried out by investigating the ability of these derivatives to induce inter- and intramolecular G-quadruplex structures by polyacrylamide gel electrophoresis (PAGE) and to inhibit telomerase in a modified TRAP assay. The two properties appear to be satisfactorily correlated and they show that the number and distances of positive charges in the side chains dramatically influence both these features. Although our previous studies on perylene derivatives with mono-positively charged side chains indicated that self assembly in aqueous solution leads to a major efficiency, the result observed with the spermine derivative suggests that a too strong aggregation is unfavourable, because it determines a lower solubility of the compounds.

Aliphatic Amino Azides as Key Building Blocks for Efficient Polyamine Syntheses

New routes to open-chain polyamines have been developed using aliphatic amino azides as common precursors for the construction of the carbon-nitrogen framework.These α,ω-diaminoalkane synthetic equivalents were combined with (ω-halogenalkyl)dichloroboranes to extend the polyamine chain from the azido moiety.An extension from the free amino group can also be achieved via a Michael type addition with acrylonitrile or a reductive amination with a γ-azido ketone.Further transformations led to a large variety of regioselectively C- or (and) N-substituted polyamines.

Isolation, characterization, and turnover of glutathionylspermidine from Escherichia coli

Most of the spermidine in E. coli is converted to glutathionylspermidine at the end of logarithmic growth. Methods are presented for the determination and isolation of glutathionylspermidine and for its characterization as γ glutamylcysteinylglycylspermidine. Isotopic experiments demonstrate that the spermidine of glutathionylspermidine is in equilibrium with free intracellular spermidine.