- Production process capable of industrially synthesizing dydrogesterone
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The invention discloses a production process capable of industrially synthesizing dydrogesterone. Easily available progesterone is used as a raw material, and dydrogesterone is prepared through the steps of carbonyl protection, bromination, debromination, photochemical ring-opening reaction, photochemical ring-closing reaction, deprotection and double bond isomerization. The production process hasthe advantages of easily available initial raw materials, and easiness in implementation of each step and higher yield; the production process is simple and convenient to operate, is green and environment-friendly, and can be easily amplified to industrial production.
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Paragraph 0039-0041
(2020/03/03)
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- PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF
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The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
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Page/Page column 62-63
(2011/11/30)
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- CHEMOSELECTIVE ETHYLENE ACETALIZATION OF α,β-UNSATURATED vis-a-vis SATURATED CARBONYL GROUPS
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The difficulties which in the past have precluded controlled acetalization of an α,β-unsaturated ketone functionality in the presence of a saturated carbonyl group can be overcome simply by making recourse to 2,4,6-collidinium p-toluenesulfonate as catalyst.
- Nitz, Theodore J.,Paquette, Leo A.
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p. 3047 - 3050
(2007/10/02)
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