- N, N -Disubstituted- N ′-acylthioureas as modular ligands for deposition of transition metal sulfides
-
First row transition metal complexes (Ni, Co, Cu, Zn) with N,N-disubstituted-N′-acylthiourea ligands have been synthesized and characterized. Bis(N,N-diisopropyl-N′-cinnamoylthiourea)nickel was found to have the lowest onset temperature for thermal decomp
- Ali, Zahra,Richey, Nathaniel E.,Bock, Duane C.,Abboud, Khalil A.,Akhtar, Javeed,Sher, Muhammad,McElwee-White, Lisa
-
p. 2719 - 2726
(2018/02/28)
-
- Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
-
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
- Sinha, Shweta,Doble, Mukesh,Manju
-
-
- Kinetic-Mechanistic and Solid-State Study of the Oxidative Addition and Migratory Insertion of Iodomethane to [Rhodium(S,O-BdiPT or N,O-ox)(CO)(PR1R2R3)] Complexes
-
Rhodium(I) carbonyl complexes containing bidentate X,O-Bid [S,O-BdiPT or N,O-ox; S,O-BdiPTH = N-benzoyl-N′,N′-(diphenyl)thiourea; N,O-oxH = 8-hydroxyquinoline] ligands of the form [Rh(X,O-Bid)(CO)(PR1R2R3)] (R1, R2, R3 = Ph or Cy) bearing different phosphine ligands, were investigated, the structural characterization of four example complexes is described and an extensive spectroscopic kinetic-mechanistic study of the oxidative addition of iodomethane thereto is discussed. Reaction with iodomethane led to RhIII-acyl species as secondary (final) products, whereas the primary RhIII-alkyl complexes, although rapidly formed, were only observed as intermediates, in small quantities for S,O-BdiPT (large S–Rh–O bite angle of 90–91°) but in significant amounts for N,O-ox complexes (less steric with a smaller N–Rh–O bite angle of 79–80°). Overall, almost an order-of-magnitude difference in rate constants was observed for the S,O-BdiPT complexes, with the PPh2Cy- and PPhCy2-bearing complexes showing the largest variation. In both the S,O-BdiPT and N,O-ox ligand systems an associative activation is inferred from the large negative ΔS≠ values. The relative reactivity of RhI-X,O-Bid complexes, where X = O, S or N, follows a surprising similar reactivity relationship when stepwise varying the PPh3, PPh2Cy, PPhCy2 and PCy3 tertiary phosphine ligands, suggesting a systematic behavior by the PR3 ligands, independent of the X,O-Bid ligand at the RhI metal center.
- Warsink, Stefan,Riekert Kotze,Janse van Rensburg, J. M. (Inus),Venter, Johan A.,Otto, Stefanus,Botha, Ebrahiem,Roodt, Andreas
-
p. 3615 - 3625
(2018/09/11)
-
- Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
-
The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibut
- Plutín, Ana M.,Alvarez, Anislay,Mocelo, Raúl,Ramos, Raúl,Castellano, Eduardo E.,da Silva, Monize M.,Villarreal, Wilmer,Pavan, Fernando R.,Meira, Cássio Santana,Filho, José Sim?o Rodrigues,Moreira, Diogo Rodrigo M.,Soares, Milena Botelho P.,Batista, Alzir A.
-
-
- Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N′-acyl thiourea complexes
-
Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N′-acyl thiourea complexes with general formulae [Pt(dppf)(L)]PF6, [dppf = 1,1′-bis(diphenylphosphino)ferrocene; L = N,N-disubstit
- Plutín, Ana M.,Alvarez, Anislay,Mocelo, Raúl,Ramos, Raúl,Castellano, Eduardo E.,Da Silva, Monize M.,Colina-Vegas, Legna,Pavan, Fernando R.,Batista, Alzir A.
-
-
- Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells
-
Abstract Four ruthenium(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea derivatives (Th) were obtained. The compounds, with the general formula trans-[Ru(PPh3)2(Th)(bipy)]PF6, interact with bovine serum alb
- Correa, Rodrigo S.,De Oliveira, Katia M.,Delolo, Fábio G.,Alvarez, Anislay,Mocelo, Raúl,Plutin, Ana M.,Cominetti, Marcia R.,Castellano, Eduardo E.,Batista, Alzir A.
-
-
- Fluorescent Styryl Dyes from 4-Chloro-2-(Diphenylamino)-1, 3-Thiazole-5-Carbaldehyde - Synthesis, Optical Properties and TDDFT Computations
-
4-Chloro-2-(diphenylamino)-1,3-thiazole-5-carbaldehyde was reacted with an active methylene compounds, cyanomethyl benzimidazole, cyanomethyl benzothiazole, barbituric acid and Meldrum's acid under Knoevenagel conditions to give novel push-pull styryl chromophores 8a-8d. The synthesized styryl chromophores were characterized by FT-IR, Mass and 1H NMR spectral analysis. The photophysical characteristics of these styryl chromophores were evaluated. The effect of solvent polarity and viscosity on the absorption and emission properties of these chromophores was studied. The structural, molecular, electronic and photophysical parameters of the push-pull dyes were studied by using density functional theory (DFT) and time dependent density functional theory (TDDFT) computations. The ratio of the ground to the excited state dipole moment of the synthesized novel styryl dyes were calculated by Bakhshiev and Bilot-Kawski correlations.
- Sekar, Nagaiyan,Umape, Prashant G.,Patil, Sharad R.
-
p. 1787 - 1800
(2015/11/24)
-
- On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted- N′-acyl thioureas
-
The rational design of anticancer drugs is one of the most promising strategies for increasing their cytotoxicity and for minimizing their toxicity. Manipulation of the structure of ligands or of complexes represents a strategy for which is possible to mo
- Plutín, Ana M.,Mocelo, Raúl,Alvarez, Anislay,Ramos, Raúl,Castellano, Eduardo E.,Cominetti, Marcia R.,Graminha, Angelica E.,Ferreira, Antonio G.,Batista, Alzir A.
-
-
- Synthesis and structural characterization of cobalt(II) and copper(II) complexes with N,N-disubstituted-N′-acylthioureas
-
A new complexes of Co(II) and Cu(II) with N,N-disubstituted-N′- acylthioureas have been prepared and characterized by elemental analysis, and spectroscopic techniques. The structure of N,N-diethyl-N′-furoylthiourea and Co(II) complexes with N,N-diethyl-N′
- O'Reilly, Beatriz,Plutin, Ana M.,Perez, Hiram,Calderon, Osmar,Ramos, Raul,Martinez, Roberto,Toscano, Ruben A.,Duque, Julio,Rodriguez-Solla, Humberto,Martinez-Alvarez, Roberto,Suarez, Margarita,Martin, Nazario
-
experimental part
p. 133 - 140
(2012/05/20)
-
- Monodentate coordination of N-[di(phenyl/ethyl)carbamothioyl]benzamide ligands: Synthesis, crystal structure and catalytic oxidation property of Cu(i) complexes
-
New four-coordinated tetrahedral copper(i) complexes have been synthesized from the reactions between [CuCl2(PPh3)2] and N-(diphenylcarbamothioyl)benzamide (HL1) or N-(diethylcarbamothioyl)benzamide (HL2) in benzene. These complexes have been characterized by elemental analyses, IR, UV/Vis, 1H, 13C and 31P NMR spectroscopy. The molecular structure of both the complexes, [CuCl(HL1)2(PPh 3)] (1) and [CuCl(HL2)(PPh3)2] (2) were determined by single-crystal X-ray diffraction, which reveals distorted tetrahedral geometry around each Cu(i) ion. The combination of 2 (0.005 mmol) with hydrogen peroxide (2.5 mmol) in acetonitrile is found to be an active catalyst for the oxidation of primary and secondary alcohols (0.5 mmol) to their corresponding acids and ketones, respectively, at room temperature. The Royal Society of Chemistry.
- Gunasekaran, Nanjappan,Ramesh, Pandian,Ponnuswamy, Mondikalipudur Nanjappa Gounder,Karvembu, Ramasamy
-
body text
p. 12519 - 12526
(2012/01/06)
-
- Synthesis, characterization, and catalytic applications of Ru(III) complexes containing N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives and triphenylphosphine/triphenylarsine
-
Six coordinated ruthenium(III) complexes of the type [RuX2(L)(PPh3)2] or [RuX2(L)(AsPh3)2] {where L = N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives, X = Cl or Br} have been prepared by the reaction between [RuX3(PPh3)3] or [RuX3(AsPh3)3] (where X = Cl or Br) and N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives in toluene and characterized by elemental analysis, spectral data (electronic, IR and EPR) and magnetic moment studies. The complexes act as efficient catalysts for the oxidation of alcohols in presence of N-methylmorpholine-N-oxide as oxidant at room temperature.
- Gunasekaran,Karvembu
-
body text
p. 952 - 955
(2011/01/07)
-
- Antimicrobial activity and structural study of disubstituted Thiourea Derivatives
-
The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included. Springer-Verlag 2007.
- Cunha, Silvio,MacEdo Jr., Fernando C.,Costa, Giselle A. N.,Rodrigues Jr., Manoel T.,Verde, Rosival B. V.,De Souza Neta, Lourdes C.,Vencato, Ivo,Lariucci, Carlito,Sa, Fernando P.
-
p. 511 - 516
(2008/02/03)
-
- Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media
-
1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent- free conditions on potassium fluoride impregnated alumina. Yields were dramatically improved in comparison with classical heating under the same conditions. (C) 2000 Published by Elsevier Science Ltd.
- Márquez, Heiddy,Pérez, Eduardo R.,Plutín, Ana M.,Morales, Margarita,Loupy, André
-
p. 1753 - 1756
(2007/10/03)
-