- BODIPY protein misfolding probe Hal-BODIPY, preparation method and application thereof
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The invention discloses a BODIPY protein misfolding probe Halo-BODIPY, a preparation method and application thereof, wherein the structural formula of the fluorescent probe is shown as a formula I inthe specification. According to the invention, the micro
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Paragraph 0041-0043; 0046; 0047
(2021/01/29)
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- FLUORESCENCE DYE
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The present invention relates to compound according to formulas (1), (15), (16) or (17), the use of the compounds as a fluorescent dye, and a fluorescent dye comprising the compounds. The invention also relates to a method for fluorescence-based identific
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Page/Page column 28; 29
(2020/07/07)
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- Preparation method of 1-chloro-6-iodohexane
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The invention discloses a preparation method of 1-chloro-6-iodohexane. The preparation method comprises the steps of with 6-chloro-1-hexanol and p-toluene sulfochloride as the materials and benzene ortoluene as a solvent, reacting at (-5)-(5) DEG C for 2-5 hours under the effects of a phase transfer catalyst and an acid-binding agent so as to prepare 4-methylbenzenesulfonic acid-6-chlorohexyl ester, and carrying out reflux reaction on 4-methylbenzenesulfonic acid-6-chlorohexyl ester and sodium iodide for 0.5-3 hours, so as to prepare 1-chloro-6-iodohexane. The preparation method has the characteristics of easiness in operation, simplicity and convenience in after-treatment and relatively high yield.
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Paragraph 0011; 0013
(2019/04/09)
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- DYES FOR ANALYSIS OF SOLUBLE PROTEIN AGGREGATES OR MISFOLDED PROTEIN OLIGOMERS
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Dye and compositions to monitor the multistep protein aggregation process in both test tubes and live cells are provided. These dyes can detect misfolded protein oligomers and distinguish insoluble protein aggregates from misfolded oligomers. Applications of these dyes include measuring kinetics of protein aggregation, monitoring aggregation of specific proteins in intact live cells, monitoring aggregation of cellular proteome in intact live cells, and tracking the time course of protein aggregation in cells under stress conditions.
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Paragraph 0099; 00100
(2019/10/01)
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- An acid/alkali double stimulus responsive nano container and its preparation method
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The invention discloses an acid/base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid/base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.
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Paragraph 0039-0041; 0057; 0073
(2018/11/22)
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- Copper-catalyzed cross-coupling reaction of organoboron compounds with primary alkyl halides and pseudohalides
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Non-activated alkyl electrophiles, including alkyl iodides, bromides, tosylates, mesylates, and even chlorides, underwent copper-catalyzed cross-coupling with aryl boron compounds and alkyl 9-BBN reagents (see scheme; 9-BBN=9-borabicyclo[3.3.1]nonane). The reactions proceed with practically useful reactivities and thus complement palladium- and nickel-catalyzed Suzuki-Miyaura coupling reactions of alkyl halides.
- Yang, Chu-Ting,Zhang, Zhen-Qi,Liu, Yu-Chen,Liu, Lei
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supporting information; experimental part
p. 3904 - 3907
(2011/05/15)
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- Pheromone synthesis. Part 244: Synthesis of the racemate and enantiomers of (11Z,19Z)-CH503 (3-acetoxy-11,19-octacosadien-1-ol), a new sex pheromone of male Drosophila melanogaster to show its (S)-isomer and racemate as bioactive
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The enantiomers of (11Z,19Z)-3-acetoxy-11,19-octacosadien-1-ol were synthesized from the enantiomers of 3,4-epoxy-1-butanol PMB ether. Its racemate was also synthesized. Its (S)-isomer and racemate were shown to possess the same pheromone activity as CH503, a long-lived inhibitor of male courtship in Drosophila melanogaster, although the racemate was less active.
- Mori, Kenji,Shikichi, Yasumasa,Shankar, Shruti,Yew, Joanne Y.
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experimental part
p. 7161 - 7168
(2010/10/01)
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- Approaches towards the synthesis of fluoro(cyclo)alkylamines
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The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.
- Windhorst,Bechger,Visser,Menge,Leurs,Timmerman,Herscheid
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- Convenient synthesis of large tetraazamacrocycles bearing alkylene, cyclophane and crown ether type skeletons
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A series of large tetraazamacrocycles with 28- to 44-membered rings consisting of alkylene, phenylene or ether type backbones has been prepared without the use of high-dilution conditions in practically significant yields (25-42%). The reaction can be car
- Tomohiro,Ahmadi Avval,Okuno
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p. 639 - 640
(2007/10/02)
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