- SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).
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Paragraph 0191; 0192; 0193
(2016/09/26)
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- COMPOUNDS AND METHODS OF USE
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This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGFβ) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.
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Paragraph 0151
(2015/07/16)
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