- As-triazine derivatives with potential therapeutic action. XXIX: Synthesis of 5-[2-(halogenobenzylthio)-ethyl]thio-6-azauracil derivatives as potential antiviral agents
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Several 2-chloroethyl-halogenobenzyl sulfides were obtained by the alkylation of sodated 2-mercaptoethanol with the corresponding halogenobenzyl halides. They reacted in hydroalcoholic medium with the sodium salt of 5-mercapto-6-azauracil to give the title compounds in 55-73% yield.
- Czobor, Francisc,Cristescu, Carol
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p. 1007 - 1011
(2007/10/03)
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- Organosulfur compounds as potential fungicides: The preparation and properties of some substituted benzyl 2-hydroxyethyl oligosulfides
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Compounds of the general type ArCH2SnCH2CH2OH (n = 1 - 4, Ar = Ph, 2-MeC6H4. 4-MeC6H4, 4-ClC6H4, 4-MeOC6H4; n = 1 - 3, Ar = 2-ClC6H4; n = 2, Ar = 4-FC6H4; n = 3 or 4, Ar = 2-furyl) have been prepared as analogues of the trisulfide PhCH2SSSCH2CH2OH (an antimicrobial compound which occurs in the plant Petiveria alliacea) and their potential for application as agricultural fungicides has been examined. In vitro tests against Fusarium culmorum, Fusarium oxysporum and Gauennmyceles graminis showed that all compounds gave > 80% control of these organisms at 1000 ppm. Tests at 100 and 10 ppm showed varying levels of control but the activity did not depend significantly on the number of sulfur atoms present. Selected compounds were also shown to be active in vivo against Erysiphe graminis on barley seedlings, Botrytis fabae and Uromyces viciae-fabae on bean seedlings, Podosphaera leucotricha on apple seedlings, and Phytophthora infestans on potato leaf. The compounds were phytotoxic at concentrations greater than 0.33%.
- Ayodele, Ezekiel T.,Hudson, Harry R.,Ojo, Isaac A. O.,Pianka, Max
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p. 123 - 142
(2007/10/03)
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