- One-Pot Mitsunobu Protocol to Access Ketene S,S-/N,S-Acetals at Room Temperature
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With unique chemical reactivity, α-oxoketene S,S- and N,S-acetals have attracted enormous attention in the past decades, whereas limited reports exist for their synthesis via eco-compatible protocols. Herein, we developed a one-pot protocol for symmetrical and unsymmetrical α-oxoketene S,S-/N,S-acetals through chemoselective alkylation of α-enolic dithioesters using Mitsunobu chemistry at room temperature. The operationally simple and user-friendly mild protocol tolerates a wide range of alcohols and α-enolic dithioesters/β-ketothioamides. Short reaction time, good yields, highly selective C?S functionalization, and E/Z-stereoselectivity are imperative characteristics of this strategy.
- Saha, Priya,Ansari, Monish Arbaz,Shukla, Gaurav,Singh, Maya Shankar
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supporting information
p. 5884 - 5888
(2021/11/27)
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- Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones
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A base-promoted strategic synthesis of various functionalized thiomethylated-benzenes has been established from aryl/heteroaryl/cyclopropyl methyl ketone. We can directly access the thiomethylated-benzene nucleus embedded with diverse functional group by
- Panwar, Rahul,Althagafi, Ismail,Shally,Shaw, Ranjay,Elagamy, Amr,Shah, Chandan,Yadav, Pratik,Pratap, Ramendra
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- Bronsted acid catalyzed PhSe transfer versus radical aryl transfer: Linear codimerization of styrenes and internal olefins
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Bronsted acid p-TsOH·H2O-catalyzed hydrovinylation of styrenes with internal olefins α-oxo ketene dithioacetals was efficiently achieved in the presence of N-phenylselenophthalimide (N-PSP), regioselectively affording Markovnikov phenylselenati
- Wu, Ping,Wang, Liandi,Wu, Kaikai,Yu, Zhengkun
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supporting information
p. 868 - 871
(2015/03/30)
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- Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations
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We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety
- Singh, Surjeet,Althagafi, Ismail,Yadav, Pratik,Panwar, Rahul,Kumar, Abhinav,Pratap, Ramendra
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p. 8879 - 8884
(2015/03/05)
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