7157-92-8

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 7052-22-4 3-phenyl-2-thioxo-2,3-dihydrothiazolo<4,5-d>pyrimidin-7(6H)-one 
• 141622-32-4 5-methyl-3-phenyl-2,3-dihydro-2-thioxothiazolo[4,5-d]pyrimidine-7(6H)-one 
• 141622-22-2 5-(4-Methoxy-phenyl)-3-phenyl-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one 
• 141622-13-1 3,5-Diphenyl-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one 
• 141622-16-4 5-methyl-3-phenyl-thiazolo<5,4-d>pyrimidin-2,7-dithione 
• 141622-21-1 7-Ethylsulfanyl-5-methyl-3-phenyl-3H-thiazolo[4,5-d]pyrimidine-2-thione 
• 141622-24-4 (5-Methyl-3-phenyl-2-thioxo-2,3-dihydro-thiazolo[4,5-d]pyrimidin-7-ylsulfanyl)-acetonitrile 
• 141622-33-5 3-(5-Methyl-3-phenyl-2-thioxo-2,3-dihydro-thiazolo[4,5-d]pyrimidin-7-ylsulfanyl)-propionitrile 
• 141622-29-9 1-(5-Methyl-3-phenyl-2-thioxo-2,3-dihydro-thiazolo[4,5-d]pyrimidin-7-ylsulfanyl)-propan-2-one 
• 141622-17-5 5-Methyl-3-phenyl-7-phenylamino-3H-thiazolo[4,5-d]pyrimidine-2-thione 
• 141622-27-7 2-(5-Methyl-3-phenyl-2-thioxo-2,3-dihydro-thiazolo[4,5-d]pyrimidin-7-ylsulfanyl)-acetamide 
• 141622-34-6 7-Benzylsulfanyl-5-methyl-3-phenyl-3H-thiazolo[4,5-d]pyrimidine-2-thione 
• 141622-26-6 5-Methyl-3-phenyl-7-p-tolylamino-3H-thiazolo[4,5-d]pyrimidine-2-thione 
• 141622-20-0 3-phenyl-5-methyl-7<3,5-dimethylpyrazol-1-yl>thiazolo<5,4-d>pyrimidin-2-thione 

Relevant academic research and scientific papers

Synthesis, Structural Characterization and Anticancer Activity of New 5-Trifluoromethyl-2-thioxo-thiazolo[4,5-d] pyrimidine Derivatives

Thiazolo[4,5-d]pyrimidine derivatives are considered potential therapeutic agents, partic-ularly in the development of anticancer drugs. In this study, new 7-oxo-(2a-e), 7-chloro-(3a-e) and also three 7-amino-(4a-c) 5-trifluoromethyl-2-thioxo-thiazolo[4,5

Synthesis and antitumor screening of novel 3-phenylthiazolo [4,5-d]pyrimidin-2-thione derivatives

A series of new derivatives of 3-phenylthiazolo[4,5-d]pyrimidine-2-thiones were synthesized by the cyclization of 4-amino-5-alkyl(aryl) carboxamido-2,3-dihydrothiazolo-2-thione with aromatic aldehydes. Amine moieties were substituted in position 7 of the obtained bicyclic compounds. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, and 13C-NMR spectral data. Some of the newly synthesized compounds were selected by the US National Cancer Institute for in vitro antitumor screening. The two compounds 3d 7-chloro-5-(4-fluorophenyl)-3- phenyl-4,5-dihydro-3H-thiazolo[4,5-d]pyrimidine-2-thione and 4i 5-(2-chlorophenyl)-7-(4-fluorobenzylamino)-3-phenyl-4,5-dihydro-3H-thiazolo[4, 5-d]pyrimidine-2-thione proved to be the most active in the present study and their antitumor activities against 60 human tumor cell lines were described. ECV Editio Cantor Verlag.

Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities

In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with -bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The structure elucidation of the obtained co

The Reaction of Active Methylene Reagents With Sulfur and Phenyl Isothiocyanate: Novel Synthesis of Thiazole, Thiazolopyrimidine, and 4,5'-Bithiazolyl Derivatives

The active methylene reagents 1a-i reacted with phenyl isothiocyanate and sulfur to afford the thiazole derivatives 2a-i.The reactivity of 2a and 2f towards various chemical reagents was studied.