- Pd-Catalyzed Highly Chemo- And Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid
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An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH is described. A wide variety of linear carboxylic acids bearing various functional groups can be obtained with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.
- Ren, Wenlong,Chu, Jianxiao,Sun, Fei,Shi, Yian
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supporting information
p. 5967 - 5970
(2019/08/26)
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- Synthetic method of terminal carboxylic acid
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The invention discloses a synthetic method of a terminal carboxylic acid. The synthetic method is characterized by comprising the steps of adding an olefin represented by a formula (3) shown in the description, formic acid, acetic anhydride, Pd(OAc)2 and a monophosphorus ligand TFPP into an organic solvent in a proportion, carrying out hydrogen carbonylation reaction on the olefin represented by the formula (3) shown in the description, formic acid and acetic anhydride at 80-90 DEG C for 48h-72h under the catalysis of the metal palladium salt Pd(OAc)2 and the monophosphorus ligand TFPP so as to obtain the terminal carboxylic acid represented by a formula shown in the description, and separating a target product, namely the terminal carboxylic acid after the reaction is finished, wherein olefin represented by the formula (3) is selected from cycloolefins, or linear olefins of which the R1 is electron donating groups. By virtue of the method disclosed by the invention, corresponding terminal carboxylic acid and a derivative thereof can be prepared through the reaction under mild conditions of low temperature and no high pressure; and the steps of the synthetic method are simple and convenient, the operation is convenient, the yield is high, the energy source can be greatly saved, and the synthetic efficiency can be greatly improved.
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Paragraph 0067-0070
(2019/11/21)
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- Site-Selective Catalytic Carboxylation of Unsaturated Hydrocarbons with CO2 and Water
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A catalytic protocol that reliably predicts and controls the site-selective incorporation of CO2 to a wide range of unsaturated hydrocarbons utilizing water as formal hydride source is described. This platform unlocks an opportunity to catalytically repurpose three abundant, orthogonal feedstocks under mild conditions.
- Gaydou, Morgane,Moragas, Toni,Juliá-Hernández, Francisco,Martin, Ruben
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supporting information
p. 12161 - 12164
(2017/09/12)
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- Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH-insensitive Inhibitory Effects on the Mitochondrial ADP/ATP Carrier
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Bongkrekic acid, isolated from Burkholderia cocovenenans, is known to specifically inhibit the mitochondrial ADP/ATP carrier. However, the manner of its interaction with the carrier remains elusive. In this study, we tested the inhibitory effects of 17 bo
- Yamamoto, Atsushi,Hasui, Keisuke,Matsuo, Hiroshi,Okuda, Katsuhiro,Abe, Masato,Matsumoto, Kenji,Harada, Kazuki,Yoshimura, Yuya,Yamamoto, Takenori,Ohkura, Kazuto,Shindo, Mitsuru,Shinohara, Yasuo
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p. 1304 - 1322
(2015/10/28)
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- Studies toward the total synthesis of sorangiolides and their analogues. A convergent stereoselective synthesis of the macrocyclic lactone precursors
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Stereosetective synthesis of the fully protected 18-membered macrocyclic lactones as the immediate precursors of the natural products, sorangiolides A and B, is described. The key steps used in the synthesis include the sp 3-hybridized carbon-carbon Fu cross coupling, the stereosetective Evans' aldol reaction with 1,5-anti induction, the 1,3-diastereoselective syn reduction of a β-hydroxyketone intermediate, and Mukaiyama macrolactonization reactions.
- Das, Sanjib,Abraham, Sunny,Sinha, Subhash C.
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p. 2273 - 2276
(2008/02/04)
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- Cyclative cleavage via solid-phase supported stabilized sulfur ylides: Synthesis of macrocyclic lactones
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A new synthesis of macrolactones bearing a cyclopropyl ring condensed to the macrocycle is reported via a cyclization-release strategy making use of solid-phase supported stabilized sulfur ylides.
- La Porta, Elena,Piarulli, Umberto,Cardullo, Francesca,Paio, Alfredo,Provera, Stefano,Seneci, Pierfausto,Gennari, Cesare
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p. 761 - 766
(2007/10/03)
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