Rhodium-Catalyzed Room Temperature C-C Activation of Cyclopropanol for One-Step Access to Diverse 1,6-Diketones
A rhodium-catalyzed room temperature C-C activation of cyclopropanol has been demonstrated for the single-step synthesis of a range of electronically and sterically distinct 1,6-diketones. This reaction proceeds efficiently in shorter reaction time following a highly atom-economical pathway. To illustrate the synthetic potential of 1,6-diketones, aldol and macrocyclization reactions have been successfully demonstrated. Preliminary mechanistic studies revealed the involvement of nonradical pathways.
Ghosh, Asit,Pati, Bedadyuti Vedvyas,Ravikumar, P. C.
supporting information
(2020/04/02)
Potential antiinflammatory compounds. I. Antiinflammatory phenylpiperidine derivatives
The syntheses of a number of amines and their derivatives, based on the phenylpiperidine nucleus, are described. Their activities on the rat paw carrageenan test are also reported. Activities comparable to that of phenylbutazone were obtained for some of
Hicks,Smith,Williamson,Day
p. 1460 - 1464
(2007/10/05)
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