- Macrocyclic derivative and assemblies formed therefrom
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The present invention is directed to a macrocyclic derivative which is formed by modification of a macrocycle. The invention further relates to assemblies formed by the self-assembly of such macrocyclic derivatives in aqueous solvent, and includes bilayer vesicles, micelles, monolayers, nanoparticles, colloidal assemblies and surface-coated assemblies.
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Page/Page column 21
(2014/10/16)
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- Poly-6-cationic amphiphilic cyclodextrins designed for gene delivery
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A new series of amphiphilic cyclodextrins containing cationic groups at the 6-positions and alkyl or biolabile ester groups at the 2-positions has been synthesised. Selective 2-O-allylation followed by photochemical addition of lipophilic thiols made it possible to control lipophilicity in these mesomolecules and allow solubility and self-assembly in water. The cationic groups are cysteamine-derived, while the alkyl and ester groups are C 1-C16 and benzyl ester groups. This is a new general synthetic route to a potentially wide range of polycationic cyclodextrins capable of acting as gene delivery vectors by condensing DNA and forming liquid crystalline complexes with oligonucleotides.
- Byrne, Colin,Sallas, Florence,Rai, Dilip K.,Ogier, Julien,Darcy, Raphael
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experimental part
p. 3763 - 3771
(2009/10/23)
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