- A Kinetic Investigation of the Hydroxide-catalysed Detritiation of Various -15,16-Dihydrocyclopentaphenanthren-17-ones and Related Compounds
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The hydroxide-catalysed detritiation rate constants from the C-16 position of a series of substituted -15,16-dihydrocyclopentaphenanthren-17-ones have been measured in a 90:10 (v/v) water-dioxane mixture at 25 deg C.The results show that methyl group substitution brings with it, in addition to the costumary deactivating effect, a marked acceleration in rate, which probably has its origin in steric strain considerations.Similar studies involving the analogous position in a number of related ketones (benzindanone, indanone, and cyclopentanone) show that the rates are not simply a function of the number of additional benzene rings but depend on their position relative to the cyclopentanone system.
- Elvidge, John A.,Jones, John R.,Russell, Jeremy C.,Wiseman, Alan,Coombs, Maurice M.
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p. 563 - 566
(2007/10/02)
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- Potentially Carcinogenic Cyclopentaphenanthrenes. Part 11. Synthesis of the 1-Methyl, 1,11-Methano, and 7,11-Dimethyl Derivatives of 15,16-Dihydrocyclopentaphenanthren-17-one
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15,16-Dihydro-1-methylcyclopentaphenanthren-17-one has been prepared starting from testosterone, and in addition by a multi-stage synthesis from a correctly substituted naphthalene.The latter route has also been employed for the synthesis of the 7,11-d
- Ribeiro, Odartey,Hadfield, Stephen T.,Clayton, Alexandra F.,Vose, Colin W.,Coombs, Maurice M.
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