720696-77-5

Basic information

• Product Name: 2-(2-NAPHTHYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• Synonyms: 2-NAPHTHALEN-2-YL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE;2-(2-NAPHTHYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
• CAS NO: 720696-77-5
• Molecular Formula: C18H12N2O
• Molecular Weight: 272.3
• Mol File: 720696-77-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-NAPHTHYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-NAPHTHYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(720696-77-5)
• EPA Substance Registry System: 2-(2-NAPHTHYL)IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE(720696-77-5)

Safety Data

• Hazardous Substances Data: 720696-77-5(Hazardous Substances Data)

Usage

Heterocyclic compound

Contains an imidazole ring fused to a pyridine ring The compound consists of two heterocyclic rings, an imidazole and a pyridine, which are fused together. Heterocyclic compounds contain one or more atoms other than carbon in the ring.

Naphthyl group

Attached to the imidazole ring A naphthyl group, which is a part of the compound, is attached to the imidazole ring, adding to the complexity and diversity of the compound's structure.

Building block

Used in the synthesis of various pharmaceutical and organic compounds The compound is commonly used as a building block or intermediate in the creation of other pharmaceutical and organic compounds due to its versatile chemical structure.

Versatile intermediate

Aldehyde group allows for the formation of new carbon-carbon and carbon-nitrogen bonds The presence of an aldehyde group in the compound makes it a valuable intermediate in organic synthesis, as it can easily form new bonds with other molecules.

Potential applications

Medicinal chemistry, drug development, specialty chemicals, and materials production The compound has a wide range of potential applications, including the development of new drugs, specialty chemicals, and materials for various industries.

Luminescent properties

Useful in the development of optical and electronic devices The compound's ability to emit light makes it a valuable material for the development of new optical and electronic devices in the field of materials science.

Upstream product

• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 38922-71-3 2‐(naphthalen‐2‐yl)imidazo[1,2‐a]pyridine 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

Novel method for constructing 2-(2-naphthyl)imidazo[1,2-a]pyridine-3-aldehyde by using DMF as formylation reagent

The invention discloses a novel method for one-step construction of 2-(2-naphthyl)imidazo[1,2-a]pyridine-3-aldehyde by taking DMF (N,N-dimethylformamide) as a formylation reagent. According to the method, 2-(2-naphthyl)imidazo[1,2-a]pyridine is used as a reaction raw material, the DMF (N,N-dimethylformamide) is used as the formylation reagent, and the 2-(2-naphthyl)imidazo[1,2-a]pyridine-3-aldehyde is constructed in one step. The method has the advantages of novel synthesis means, mild reaction conditions and cheap and easily available reaction reagents, and the N,N-dimethylformamide can be used as both a reaction solvent and the formylation reagent, thereby satisfying the development requirements of green chemistry.

Visible light induced tetramethylethylenediamine assisted formylation of imidazopyridines

A metal-free visible light induced C-3 formylation of imidazo[1,2-a]pyridine has been developed using tetramethylethylenediamine (TMEDA) as a one carbon source. An array of 3-formyl imidazo[1,2-a]pyridines with wide functionality are synthesized using rose bengal as a photosensitizer under ambient air.