72111-57-0

Basic information

• Product Name: 5-Chloro-2,3-pyrazinedicarbonitrile
• Synonyms: 5-Chloro-2,3-pyrazinedicarbonitrile;5-Chloropyrazine-2,3-dicarbonitrile
• CAS NO: 72111-57-0
• Molecular Formula: C₆HClN₄
• Molecular Weight: 0
• Mol File: 72111-57-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Chloro-2,3-pyrazinedicarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2,3-pyrazinedicarbonitrile(72111-57-0)
• EPA Substance Registry System: 5-Chloro-2,3-pyrazinedicarbonitrile(72111-57-0)

Safety Data

• Hazardous Substances Data: 72111-57-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2,3-pyrazinedicarbonitrile is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
5-Chloro-2,3-pyrazinedicarbonitrile is used as an intermediate in the manufacture of herbicides and insecticides, playing a crucial role in the production of agricultural chemicals to protect crops.
Used in Materials Science:
5-Chloro-2,3-pyrazinedicarbonitrile has potential applications in the field of materials science, where it can be utilized in the development of new materials with specific properties.
Used in Organic Synthesis:
5-Chloro-2,3-pyrazinedicarbonitrile is used as an intermediate in organic synthesis, enabling the creation of various organic compounds for different applications.
Safety Precautions:
It is important to handle 5-Chloro-2,3-pyrazinedicarbonitrile with care, as it may cause irritation to the skin, eyes, and respiratory system. It should be stored and used in a well-ventilated area to minimize exposure risks.

Upstream product

• 57005-60-4 2,3-Dicyano-5-hydroxypyrazine 

Downstream Products

• 72111-86-5 5-m-tolyloxy-pyrazine-2,3-dicarbonitrile 
• 72111-85-4 5-o-tolyloxy-pyrazine-2,3-dicarbonitrile 
• 72111-84-3 5-(4-chloro-phenoxy)-pyrazine-2,3-dicarbonitrile 
• 72111-88-7 5-(4-methoxy-phenoxy)-pyrazine-2,3-dicarbonitrile 
• 72112-13-1 2,3-Dicyano-5-anilinopyrazine 
• 72112-08-4 2,3-Dicyano-5-benzylthiopyrazine 
• 72112-05-1 5-(4-chloro-phenylsulfanyl)-pyrazine-2,3-dicarbonitrile 
• 72112-19-7 5-(benzylamino)pyrazine-2,3-dicarbonitrile 
• 72111-90-1 5-(2,4-dichloro-phenoxy)-pyrazine-2,3-dicarbonitrile 
• 72111-92-3 5-(3,4-dimethyl-phenoxy)-pyrazine-2,3-dicarbonitrile 
• 72111-93-4 5-(4-chloro-3-methyl-phenoxy)-pyrazine-2,3-dicarbonitrile 
• 72111-87-6 5-p-tolyloxy-pyrazine-2,3-dicarbonitrile 
• 72112-07-3 2,3-Dicyano-5-(3-methylphenylthio)pyrazine 
• 72111-83-2 5-(2-chloro-phenoxy)-pyrazine-2,3-dicarbonitrile 

Relevant articles and documents

OFF-ON-OFF Red-Emitting Fluorescent Indicators for a Narrow pH Window

A unique combination of two independent mechanisms of fluorescence quenching, namely intramolecular charge transfer (ICT) from a peripheral donor and protonation of azomethine nitrogen atoms in zinc tetrapyrazinoporphyrazines (TPyzPz), provides a new possibility for sensing pH in a specific range. The pH selectivity was controlled by the different basicities of the donor for ICT (dimethylaminoaryl), which was connected to the macrocycle by π-extended linkers of different lengths. ICT and protonation have been studied in detail by photophysical, spectral (UV/Vis and MCD spectra), and electrochemical measurements, and further supported by theoretical calculations (DFT, TDDFT). The pH-sensing properties of the TPyzPzs have been investigated in THF and in water after anchoring the TPyzPzs to liposomes. The salient pKavalues were around 1.3 (azomethine nitrogen) and 2.29–4.76 (donor for ICT). The lead indicators (sensing over a pH range of 1.0–2.5) with fairly steep sensing profiles exhibited increases in fluorescence between the OFF/ON states of more than 20-fold and strong absorption in the red region (Q-band maximum >650 nm, ?≈2×106m?1cm?1).

Structure-activity Relationship of Herbicidal 2,3-Dicyano-5-Substituted Pyrazines

Sixty six 2,3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity.The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.

Structure-activity Relationships of Herbicidal 5-Ethylamino- and 5-Propylamino-2,3-Dicyanopyrazines

Sixty-eight 6-substituted 5-ethylamino- and 5-propylamino-2,3-dicyanopyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests.The most active compound was 2,3-dicyano-5-propylamino-6-(m-chlorophenyl)pyra

2,3-Dicyanopyrazines

Novel 2,3-dicyanopyrazine derivatives of the formula STR1 wherein A represents a hydrogen atom, a lower alkyl group, an unsubstituted or substituted phenyl group, a benzyl group, or a group of the formula -ZR1 in which Z represents an oxygen or