- Propionic Acid Derivatives and Methods of Use Thereof
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Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.
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Paragraph 1811; 1813
(2018/11/21)
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- MEK INHIBITOR SALTS AND SOLVATES THEREOF
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The present invention relates to sodium salt forms of 7-(4-Bromo-2-fluoro- phenylamino)-6-methyl-5-oxo-1,3,5-tetrahydro-indolizine-8-carboxylic acid (2- hydroxyethoxy)-amide and 7-(4-Bromo-2-fluoro-phenylamino)-5-oxo- 1,2,3,5-tetrahydro- indolizine-8-carboxylic acid cyclopropylmethoxy-amide and their corresponding solvates and polymorphs, which are useful in the treatment of a disease, disorder or syndrome associated with MEK inhibition, such as cancer, in mammals.
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Page/Page column 16; 26
(2011/06/25)
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- Heterocyclic Compounds as MEK Inhibitors
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The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.
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Page/Page column 18
(2009/12/02)
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- Unexpected ring size effect of the annulation reaction of heterocyclic secondary enamines with dicarboxylic acid dichlorides
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Heterocyclic enamines are versatile ambident nucleophilic reagents able to react with both aliphatic and aromatic dicarboxylic acid dichlorides in diverse manners. The reaction outcome was strongly dependent upon the heterocyclic structure of the enamines
- Cheng, Ying,Yang, Hai-Bo,Wang, Mei-Xiang,Williams, David J
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p. 2821 - 2829
(2007/10/03)
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- Annulation of heterocyclic secondary enamines with dicarboxylic acid dichlorides, an unexpected ring size effect
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Under very mild conditions heterocyclic secondary enamines react efficiently with malonyl chloride to produce hydroxylated 2-pyridinone-fused heterocycles. The reactions of enamines with oxalyl chloride, however, afford varied products depending upon the heterocyclic structure of the enamine. Whilst a C-acylated enamine and a lactam-fused heterocycle were obtained from the reaction of the five- and seven-membered heterocyclic enamines, respectively, the six-membered heterocyclic enamine gave 2-oxo-5,6,7,8-tetrahydro-2H-pyrido[3,2-b]pyran. The reaction mechanisms are discussed.
- Cheng, Ying,Yang, Hai-Bo,Huang, Zhi-Tang,Wang, Mei-Xiang
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p. 1757 - 1759
(2007/10/03)
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