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(R)-2-Amino-3-(4-ethylphenyl)propanoic acid, also known as 4-ethyl-D-phenylalanine, is a chiral amino acid derivative with a unique structure featuring an ethyl-substituted phenyl group. It exhibits specific stereochemistry and functional groups that make it a valuable compound in various chemical and pharmaceutical applications.

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  • 721385-17-7 Structure
  • Basic information

    1. Product Name: (R)-2-Amino-3-(4-ethylphenyl)propanoic acid
    2. Synonyms: (R)-2-AMINO-3-(4-ETHYLPHENYL)PROPANOIC ACID;D-4-Ethylphenylalanine; D-Phenylalanine, 4-ethyl-;4-Ethyl-D-phenylalanine;(2R)-2-Amino-3-(4-ethylphenyl)propanoic acid
    3. CAS NO:721385-17-7
    4. Molecular Formula: C11H15NO2
    5. Molecular Weight: 193.24
    6. EINECS: N/A
    7. Product Categories: Amino Acid Derivatives;unnatural amino acids
    8. Mol File: 721385-17-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 335.4°C at 760 mmHg
    3. Flash Point: 156.7°C
    4. Appearance: /
    5. Density: 1.135g/cm3
    6. Vapor Pressure: 4.72E-05mmHg at 25°C
    7. Refractive Index: 1.559
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 2.23±0.10(Predicted)
    11. CAS DataBase Reference: (R)-2-Amino-3-(4-ethylphenyl)propanoic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: (R)-2-Amino-3-(4-ethylphenyl)propanoic acid(721385-17-7)
    13. EPA Substance Registry System: (R)-2-Amino-3-(4-ethylphenyl)propanoic acid(721385-17-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 721385-17-7(Hazardous Substances Data)

721385-17-7 Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-2-Amino-3-(4-ethylphenyl)propanoic acid is used as a reagent in pharmaceutical synthesis for the development of novel drugs and therapeutic agents. Its unique structure and chirality allow for the creation of enantioselective compounds with distinct biological activities.
Used in Tuberculosis Treatment Design:
As a derivative of D-phenylalanine, (R)-2-Amino-3-(4-ethylphenyl)propanoic acid plays a crucial role in the synthesis of Schaeffer's acid analogues, which are important structures in the design of tuberculostatic agents. These analogues have the potential to target and inhibit the growth of Mycobacterium tuberculosis, the causative agent of tuberculosis, offering new treatment options for this challenging disease.

Check Digit Verification of cas no

The CAS Registry Mumber 721385-17-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,1,3,8 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 721385-17:
(8*7)+(7*2)+(6*1)+(5*3)+(4*8)+(3*5)+(2*1)+(1*7)=147
147 % 10 = 7
So 721385-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO2/c1-2-8-3-5-9(6-4-8)7-10(12)11(13)14/h3-6,10H,2,7,12H2,1H3,(H,13,14)/t10-/m1/s1

721385-17-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-amino-3-(4-ethylphenyl)propanoic acid

1.2 Other means of identification

Product number -
Other names 4-ETHYL-D-PHENYLALANINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:721385-17-7 SDS

721385-17-7Relevant articles and documents

Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades

Walton, Curtis J. W.,Parmeggiani, Fabio,Barber, Janet E. B.,McCann, Jenna L.,Turner, Nicholas J.,Chica, Roberto A.

, p. 470 - 474 (2017/12/15)

d-Phenylalanine derivatives are valuable chiral building blocks for a wide range of pharmaceuticals. Here, we developed stereoinversion and deracemization biocatalytic cascades to synthesize d-phenylalanine derivatives that contain electron-donating or -withdrawing substituents of various sizes and at different positions on the phenyl ring with a high enantiomeric excess (90 to >99 % ee) from commercially available racemic mixtures or l-amino acids. These whole-cell systems couple Proteus mirabilis l-amino acid deaminase with an engineered aminotransferase that displays native-like activity towards d-phenylalanine, which we generated from Bacillus sp. YM-1 d-amino acid aminotransferase. Our cascades are applicable to preparative-scale synthesis and do not require cofactor-regeneration systems or chemical reducing agents.

Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

Parmeggiani, Fabio,Ahmed, Syed T.,Thompson, Matthew P.,Weise, Nicholas J.,Galman, James L.,Gahloth, Deepankar,Dunstan, Mark S.,Leys, David,Turner, Nicholas J.

, p. 3298 - 3306 (2016/10/20)

A practical and efficient biocatalytic synthesis of aromatic d-amino acids has been developed, based on the reductive amination of the corresponding α-keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofactor recycling apparatus. The reaction was shown to give excellent enantioselectivity (≥98%) and good yields at the preparative scale across a broad range of substrates. Additionally, the structure of the variant enzyme was solved to allow rationalisation of the observed reaction rates. The engineered whole cell catalyst was also used to mediate the production of d-phenylalanine derivatives from racemic mixtures and cheaper l-amino acids by combining it with an enantiocomplementary deaminase. (Figure presented.).

Phenylalanine aminomutase-catalyzed addition of ammonia to substituted cinnamic acids: A route to enantiopure α- and β-amino acids

Szymanski, Wiktor,Wu, Bian,Weiner, Barbara,De Wildeman, Stefaan,Feringa, Ben L.,Janssen, Dick B.

supporting information; experimental part, p. 9152 - 9157 (2010/03/01)

(Chemical Equation Presented) An approach is described for the synthesis of aromatic α- and β-amino acids that uses phenylalanine aminomutase to catalyze a highly enantioselective addition of ammonia to substituted cinnamic acids. The reaction has a broad scope and yields substituted α- and β-phenylalanines with excellent enantiomeric excess. The regioselectivity of the conversion is determined by substituents present at the aromatic ring. A box model for the enzyme active site is proposed, derived from the influence of the hydrophobicity of substituents on the enzyme affinity toward various substrates.

Analogues of 8-D-homoarginine vasopressin

-

, (2008/06/13)

Analogues of 8-D-homoarginine vasopressin were prepared with the general formula STR1 where X is L-O-methyltyrosine, L-p-ethylphenylalanine, D-p-ethylphenylalanine, L-p-methylphenylalanine or D-methylphenylalanine and R is cysteine or β-mercaptopropionic acid. These vasopressin analogues exhibited an increased affinity to uterus receptors for oxytocin, where they acted as ocytocin antagonists. Moreover, the analogues of deamino vasopressin have a significantly reduced antidiuretic activity in comparison with [8-D-arginine]vasopressin.

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