721426-56-8

Basic information

• Product Name: 4-(ISOPENTYLOXY)BENZOHYDRAZIDE
• Synonyms: 4-(ISOPENTYLOXY)BENZOHYDRAZIDE
• CAS NO: 721426-56-8
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.28352
• Mol File: 721426-56-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(ISOPENTYLOXY)BENZOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(ISOPENTYLOXY)BENZOHYDRAZIDE(721426-56-8)
• EPA Substance Registry System: 4-(ISOPENTYLOXY)BENZOHYDRAZIDE(721426-56-8)

Safety Data

• Hazardous Substances Data: 721426-56-8(Hazardous Substances Data)

Upstream product

• 5365-43-5 ethyl 4-butoxybenzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 252896-02-9 C₁₄H₂₀O₃ 

Downstream Products

• 1630012-48-4 C₁₃H₁₆N₂O₃ 
• 1630012-62-2 C₁₇H₂₇N₃O₃ 
• 1630013-11-4 4-butyl-5-(4-isopentyloxyphenyl)-2H-1,2,4-triazole-3(4H)-one 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.

Self-assembly of highly luminescent bi-1,3,4-oxadiazole derivatives through electron donor-acceptor interactions in three-dimensional crystals, two-dimensional layers and mesophases

We report on the synthesis and self-assembly of a new series of highly luminescent bi-1,3,4-oxadiazole derivatives [2,2′-bis(4-alkoyphenyl)-bi-1, 3,4-oxadiazole, BOXD-n, n = 1, 3, 4, 5, 6, 7, 10, 16]. Fully conjugated conformations were demonstrated either by computer simulation or in a single-crystal state. Well-defined 3D donor-acceptor (DA) architectures with strong face-to-face and edge-to-edge donor-acceptor interactions were observed in the single-crystal structure of BOXD-1. Highly oriented face-on two-dimensional DA layered structures due to edge-to-edge donor-acceptor interactions were observed on highly oriented pyrolytic graphite (HOPG) in BOXD-7 and BOXD-16. Nematic phase, smectic C phase with large tilted angle ( ≈ 50°) and relatively large transition enthalpic values and a highly ordered smectic X phase were demonstrated in BOXD-n (n = 5, 6, 7, 8, 10, 16) through tailing the terminal chains and relatively large scale monodomains were prepared in the smectic X phase of BOXD-5 even without any surface treatment. Strong blue fluorescent emissions were observed in BOXD-6 either in cyclohexane (ΦF ≈ 92%) or in solid state (ΦF ≈ 57%). The donor-acceptor interactions between alkyoxyphenylene rings and 1,3,4-oxadiazole rings were thought to be the driving force for the molecules to self-assemble into a large angle tilted layered structure.