Nickel-catalyzed Kumada cross-coupling reactions of tertiary alkylmagnesium halides and aryl bromides/triflates
We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.
Joshi-Pangu, Amruta,Wang, Chao-Yuan,Biscoe, Mark R.
supporting information; experimental part
p. 8478 - 8481
(2011/06/25)
FUSED AMINO PYRIDINE AS HSP90 INHIBITORS
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.
-
Page/Page column 56
(2008/12/08)
More Articles about upstream products of 7228-36-6