Selenium dioxide oxidation of steroidal 1,4-dien-3-ones. A simple and convenient route to 6-hydroxycorticosteroids
A convenient one-step procedure for the chemical synthesis of 6-hydroxycorticosteroids involving allylic oxidation of selenium dioxide is described.
Terasawa,Okada
p. 307 - 317
(2007/10/02)
Synthesis and topical antiinflammatory potencies of a series of 6-keto- and Δ6-6-acyloxybetamethasone derivatives
6-Keto and Δ6-6-acyloxybetamethasone esters were synthesized, and tested for topical antiinflammatory potency using a modification of the Tonelli croton ear assay. The introduction of a 6-keto group generally led to retention of topical antiinflammatory potencies when compared to the corresponding 6-desoxycorticoids. In contrast, introduction of the Δ6-6-acyloxy moiety into betamethasone 17,21-dipropionate reduced antiinflammatory potency.
Draper,Berkenkopf,Carlon,Fernandez,Monahan,Lutsky
p. 317 - 322
(2007/10/02)
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