Asymmetric hydrogenation of o-alkoxy-substituted arylenamides
A series of (2-alkoxyaryl)glycinols have been prepared in up to 97.8% ee by asymmetric hydrogenation with cationic rhodium Me-BPE or Me-DuPhos complexes. Others have shown that the presence of ortho substituents on related α-arylenamides causes a decrease in enantioselectivity. However, in this study it was found that o-alkoxy α-arylenamides were reduced with high enantioselectivity irrespective of substituent size.
Cong-Dung Le, Julie,Pagenkopf, Brian L.
p. 4177 - 4180
(2007/10/03)
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