726206-53-7

Basic information

• Product Name: 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde
• Synonyms: 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde;1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde;2-HYDROXY-4-IODONICOTINALDEHYDE
• CAS NO: 726206-53-7
• Molecular Formula: C₆H₄INO₂
• Molecular Weight: 249.00593
• Mol File: 726206-53-7.mol

Chemical Properties

• Boiling Point: 345.7±42.0 °C(Predicted)
• Appearance: /
• Density: 2.11±0.1 g/cm3(Predicted)
• PKA: 8.92±0.10(Predicted)
• CAS DataBase Reference: 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde(726206-53-7)
• EPA Substance Registry System: 4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde(726206-53-7)

Safety Data

• Hazardous Substances Data: 726206-53-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde is used as a versatile building block for the production of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and reactivity make it a valuable tool for chemists and researchers looking to develop new compounds and drugs.
Used in Organic Synthesis:
4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde is used as a precursor in the synthesis of pyridine derivatives and other heterocyclic compounds. Due to its potential as a key intermediate in organic chemistry, it is of significant interest in the scientific community.

Upstream product

• 1628-89-3 2-methoxypyridine 
• 158669-26-2 4-iodo-2-methoxynicotinaldehyde 

Downstream Products

• 1025721-07-6 1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 1025720-94-8 BMS-777607 
• 1439877-05-0 N-(4-((2-acetamidopyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-(methylamino)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439878-82-6 1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxylic acid [4-(2-acetylaminopyridin-4-yloxy)-2,5-difluorophenyl]amide 
• 1439878-75-7 N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439876-98-8 N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,5-difluorophenyl)-4-(ethylamino)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1025721-21-4 1-(4-fluoro-phenyl)-4-iodo-2-oxo-1,2-dihydro-pyridine-3-carbonyl chloride 
• 1025721-10-1 1-(4-fluoro-phenyl)-4-iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 

Relevant articles and documents

PHOSPHONATE CONJUGATES AND USES THEREOF

Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

PYRROLO PYRIMIDINE DERIVATIVE

The compound represented by general formula (I) has strong Axl inhibition activity by means of a pyridone ring structure being introduced into a pyrrolo pyrimidine skeleton, and so the result can serve as a treatment agent for Axl-related diseases, for example cancers such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glial tumors, renal disease, immune system disorders, and cardiovascular disease.

PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Formula (I). Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4- ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the met kinase superfamily

Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)- 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were identified as potent and selective Met kinase inhibitors. Substitution of the pyridine 3-position gave improved enzyme potency, while substitution of the pyridone 4-position led to improved aqueous solubility and kinase selectivity. Analogue 10 demonstrated complete tumor stasis in a Met- dependent GTL-16 human gastric carcinoma xenograft model following oral administration. Because of its excellent in vivo efficacy and favorable pharmacokinetic and preclinical safety profiles, 10 has been advanced into phase I clinical trials.

PYRIDINONE COMPOUNDS

The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as ca