- PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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Paragraph 00248; 00250
(2020/05/19)
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- SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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Page/Page column 177
(2020/11/12)
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- SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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Page/Page column 184; 185
(2020/11/12)
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- A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces
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Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association.
- Ling, Xiujun,Wilcox, Craig S.
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p. 14010 - 14014
(2019/11/14)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).
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Page/Page column 142
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 322; 323; 335; 336
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 144
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 127; 128
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for the modulation of elF2B and the integrated stress response (ISR) signaling pathway and for treating related diseases, disorders and conditions.
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Page/Page column 121
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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Page/Page column 174
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 313
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds of formula (I) and (II), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 161; 210
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 140
(2017/12/13)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 295-296
(2017/12/14)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 128; 129
(2017/12/14)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 380
(2017/12/15)
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- PYRAZOLE AMIDE DERIVATIVE
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The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
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- PYRIMIDO- [4, 5-B] -OXAZINES FOR USE AS DGAT INHIBITORS
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Formula (I). Compounds of formula (I) or salts thereof, wherein A1, and R1 to R5 are as defined in the specification, are DGAT-1 inhibitors and are thereby useful in the treatment of, for example, obesity. Processes to make compounds of formula (I) are also described.
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Page/Page column 60-61
(2008/06/13)
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- Synthesis of 4-Substituted Bicyclooct-1-yl Fluorides
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The main details of the synthesis of a series of 4-substituted (X) bicyclooct-1-yl fluorides (1), which were required for substituent effect studies, are presented.The synthesis of most of these compounds 1, X = NO2, CN, CONH2, COCH3, CHO, OCH3, O
- Adcock, William,Abeywickrema, Anil N.
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p. 2951 - 2957
(2007/10/02)
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